Ignite Creation Date:
2024-05-05 @ 4:54 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00342342
Status:
COMPLETED
Last Update Posted:
2020-04-21
First Post:
2006-06-19
Brief Title:
Family Studies of Eye Traits
Sponsor:
National Human Genome Research Institute NHGRI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Family Studies of Ocular Traits
Status:
COMPLETED
Status Verified Date:
2020-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine blood specimens from patients with various eye disorders who previously participated in the Beaver Dam Eye Study to try to identify genes responsible for these disorders The Beaver Dam study was designed to determine the incidence and causes of age-related eye conditions including cataract changes in the lens of the eye that can impair vision retinopathy diseases of the retina - the thin layer of tissue that lines the back of the eye age-related maculopathy degeneration or atrophy of the macula - the center part of the retina responsible for fine vision and impaired vision Findings from this study and others have shown that age-related eye disorders often run in families indicating a genetic component in their development
All participants in the Beaver Dam study who had family members in the study may be included in the current NHGRI study The Beaver Dam study included residents of the township of Beaver Dam Wisconsin who were between 45 and 84 years of age at enrollment Participants had thorough eye examinations and blood samples drawn at baseline and 5 and 10 years after the baseline evaluation Fifteen-year follow-ups will start in 2003
This study will analyze data and blood samples previously collected from Beaver Dam study participants to identify genes related to numerous age-related visual traits No new participants will be recruited
All participants in the Beaver Dam study who had family members in the study may be included in the current NHGRI study The Beaver Dam study included residents of the township of Beaver Dam Wisconsin who were between 45 and 84 years of age at enrollment Participants had thorough eye examinations and blood samples drawn at baseline and 5 and 10 years after the baseline evaluation Fifteen-year follow-ups will start in 2003
This study will analyze data and blood samples previously collected from Beaver Dam study participants to identify genes related to numerous age-related visual traits No new participants will be recruited
Detailed Description:
The Beaver Dam Eye Study was designed to determine the long-term incidence and causes of cataract age-related maculopathy ARM retinopathy and impaired vision Age-related macular degeneration and cataract are leading causes of loss of vision in the United States In Beaver Dam preliminary analyses indicate that in those people who were 75 years of age at the baseline examination 72 developed nuclear cataract 39 developed cortical cataract 22 developed posterior subcapsular cataract PSC 37 developed early ARM large soft indistinct drusen retinal pigment epithelial RPE depigmentation and increased retinal pigment 10 developed signs of late ARM exudative macular degeneration and geographic atrophy 37 developed some impairment of vision and 6 developed severely impaired vision by the 10-year follow-up Thus these are common problems in older persons Because people 75 years of age and older are the most rapidly growing segment of the population with an estimated increase of over 60 in the next 25 years these problems pose a societal burden due to the large number of older persons they will affect Additionally we have observed substantial familial aggregation for several of these traits ARM nuclear cataract cortical cataract and ocular refraction The primary goal of this proposal is to perform linkage analysis on data collected as part of the Beaver Dam eye study NHGRI investigators will be involved in the analysis of coded data only Dr Bailey-Wilson may provide financial support to help cover the cost of DNA extraction from her budgets but NO samples will be sent to NHGRI All NHGRI effort on this study will be funded through Dr Bailey-Wilson s intramural budget
In addition to the data from the Beaver Dam Eye study we will also analyze previously existing data on glaucoma intraocular pressure and cup-disc ratio from the Framingham Eye Study FES which is a substudy of the well known cohort study called the Framingham Heart Study FHS We will perform both linkage and association analysis of these data for comparison to the results found in the BDES data
In addition to the data from the Beaver Dam Eye study we will also analyze previously existing data on glaucoma intraocular pressure and cup-disc ratio from the Framingham Eye Study FES which is a substudy of the well known cohort study called the Framingham Heart Study FHS We will perform both linkage and association analysis of these data for comparison to the results found in the BDES data
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-HG-N067 | None | None | None |