Ignite Creation Date:
2024-05-06 @ 12:55 PM
Last Modification Date:
2024-10-26 @ 1:06 PM
Study NCT ID:
NCT03882931
Status:
UNKNOWN
Last Update Posted:
2019-11-19
First Post:
2019-03-19
Brief Title:
Functional Roles of Dorsolateral Prefrontal Cortex
Sponsor:
University of Virginia
Organization:
University of Virginia
Study Overview
Official Title:
Functional Roles of Dorsolateral Prefrontal Cortex in Visuomotor Adaptation and Response Selection
Status:
UNKNOWN
Status Verified Date:
2019-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Dorsolateral prefrontal cortex DLPFC has been found to be involved in cognitive functions such as executive function response selection and working memory By applying transcranial magnetic stimulation TMS or transcranial focused ultrasound FUS which is a technology to temporally alter brain state in the stimulation site the investigators aim to find supporting evidence for the causal relationship between the targeted stimulation site and motor learning improvement or response selection
Detailed Description:
The purpose of this study is to test the functions of dorsolateral prefrontal cortex in human motor learning Dorsolateral prefrontal cortex DLPFC has been found to be involved in cognitive functions such as executive function response selection and working memory Recent Findings hint potential involvement of dorsolateral prefrontal cortex in motor learning Rare studies provided supporting evidence on its involvement and functions This study aims to examine the functional roles of dorsolateral prefrontal cortex in human motor learning By applying transcranial magnetic stimulation TMS or transcranial focused ultrasound FUS which is a technology to temporally alter brain state in the stimulation site the investigators aim to find supporting evidence for the causal relationship between the targeted stimulation site and motor learning improvement or response selection
Young healthy adults will be recruited and randomly assigned to one of four experimental groups If randomized into one of the TMS groups participants will learn to adapt to two visual rotations 20 and 60 degrees when reaching for a virtual target subjects will receive repetitive TMS rTMS stimulation over the targeted location left DLPFC or right DLPFC depending on the study group How rTMS stimulation influencing the acquisition and retention of motor memory will be assessed based on group comparison of behavioral measures such as reaching accuracy If randomized into the FUS group participants will complete a flanker task to focuses on the assessment of response selection and inhibitory control
Young healthy adults will be recruited and randomly assigned to one of four experimental groups If randomized into one of the TMS groups participants will learn to adapt to two visual rotations 20 and 60 degrees when reaching for a virtual target subjects will receive repetitive TMS rTMS stimulation over the targeted location left DLPFC or right DLPFC depending on the study group How rTMS stimulation influencing the acquisition and retention of motor memory will be assessed based on group comparison of behavioral measures such as reaching accuracy If randomized into the FUS group participants will complete a flanker task to focuses on the assessment of response selection and inhibitory control
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None