Ignite Creation Date:
2024-05-05 @ 4:54 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00341692
Status:
COMPLETED
Last Update Posted:
2020-04-29
First Post:
2006-06-19
Brief Title:
Studying Normal Breast Tissue and Cancer Risk
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Pilot Study to Collect Normal Breast Tissue From Organ and Tissue Donors
Status:
COMPLETED
Status Verified Date:
2020-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Breast cancer is the most common cancer among women in the United States Breast cancer research has been hampered by the difficulty in collecting normal breast tissue In this study researchers will obtain samples of normal breast tissue from organ donors and will collect risk-factor data from next-of-kin
The purpose of this study is to learn how normal breast develops and responds to stresses that are known to increase a woman s chance of developing breast cancer
Following the breast-tissue donation from 20 volunteers surgical technicians will make small incisions in the skin and tissue of the breast and remove several samples measuring about one-inch Technicians also will take samples of the uterine lining to estimate the date of the last menstrual period The tissue will then be sent to the National Cancer Institute for laboratory research studies Steps will be taken to ensure that the identity of the participants remains confidential
The purpose of this study is to learn how normal breast develops and responds to stresses that are known to increase a woman s chance of developing breast cancer
Following the breast-tissue donation from 20 volunteers surgical technicians will make small incisions in the skin and tissue of the breast and remove several samples measuring about one-inch Technicians also will take samples of the uterine lining to estimate the date of the last menstrual period The tissue will then be sent to the National Cancer Institute for laboratory research studies Steps will be taken to ensure that the identity of the participants remains confidential
Detailed Description:
This pilot project funded by a Breast Cancer Faculty Infrastructure Award would determine the feasibility of obtaining samples of normal breast tissue from organ donors and collecting risk factor data from next-of-kin The underlying goal of this initiative is to determine the associations between stages of breast development risk factors for breast cancer and gene expression The study investigators are members of DCEG CCR and the Transplant Resource Center of Maryland TRC a non-profit organization certified by HCFA and the state that processes most organ and tissue donations in Maryland Trained staff or social workers employed by TRC who routinely obtain consent for donation from next-of-kin will also obtain consent for this study The existing consent form for organ or tissue donation also includes informed consent for donation of tissue for research Following organ procurement from 20 volunteers trained surgical technicians employed by TRC who routinely assist intra-operatively will sterilely remove tissue from each breast quadrant and split the samples one portion will be embedded in OCT and snap frozen in liquid nitrogen and the other fixed in 10 buffered formalin Samples of adipose tissue blood urine and endometrium for menstrual dating will also be obtained MES in conjunction with SMH and BKV will assess the samples histopathologically and determine the quantity and quality of macromolecules RNA DNA protein contained within the tissues Pending demonstration of the feasibility of this general approach we will pursue additional funding for a larger study with optimized procedures We have stopped recruiting patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-C-N158 | None | None | None |