Ignite Creation Date:
2024-05-05 @ 4:54 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00342030
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2006-06-19
Brief Title:
Dietary and Genetic Factors in Asthma Chronic Bronchitis in a Cohort of Chinese Singaporeans
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Dietary and Genetic Factors in Asthma Chronic Bronchitis in a Cohort of Chinese Singaporeans
Status:
COMPLETED
Status Verified Date:
2012-04-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
There is suggestive evidence for a role of dietary in the etiology of asthma and chronic bronchitis However there are few prospective data We propose to expand our collaboration with the Singapore Chinese Health Study to examine dietary environmental and genetic factors along with their interactions in relation to the risk of developing asthma and chronic bronchitis The Singapore Chinese Health Study is a cohort of 63257 men and women of Chinese ethnicity in Singapore who were aged 45-74 years at enrollment from 1993 to 1998 Telephone follow-up of the cohort to update and outcome information began in 1999 and is ongoing We expect to identify 538 cases of incident asthma and 672 cases of incident chronic bronchitis when the current follow-up questionnaire cycle is complete in 2004 In this proposal we would validate self-reports of incident asthma obtain follow-up data from the entire cohort to perform analyses of dietary and smoking in relation to these outcomes and analyze genetic material on cases of incident asthma and chronic bronchitis and controls from the cohort In this proposal we will examine the following hypotheses
1 Higher intake of fruits andor antioxidant micronutrients decreases the risk of developing asthma and chronic bronchitis
a Effects if fruit andor antioxidant micronutrients may differ by smoking history
2 Common polymorphisms in genes involved in the response to oxidative stress influence the risk of asthma and chronic Bronchitis We initially propose to examine polymorphisms in three genes--glutathione S-tranferase M1 glutahione S-transferase P1 and matrix metalloproteinase-1 However we plan to examine additional relevant polymorphisms in the future especially taking advantage of high throughput screens of candidate genes for asthma and chronic bronchitis It is possible that by 2004 when the sample set will be available that more compelling candidates and high throughput screens may be available to us at a low cost Thus we will re-evaluate our choice when the samples are available
3 Polymorphisms in these and other genes interact with fruitantioxidant intake andor smoking to influence the risk of asthma and chronic bronchitis
1 Higher intake of fruits andor antioxidant micronutrients decreases the risk of developing asthma and chronic bronchitis
a Effects if fruit andor antioxidant micronutrients may differ by smoking history
2 Common polymorphisms in genes involved in the response to oxidative stress influence the risk of asthma and chronic Bronchitis We initially propose to examine polymorphisms in three genes--glutathione S-tranferase M1 glutahione S-transferase P1 and matrix metalloproteinase-1 However we plan to examine additional relevant polymorphisms in the future especially taking advantage of high throughput screens of candidate genes for asthma and chronic bronchitis It is possible that by 2004 when the sample set will be available that more compelling candidates and high throughput screens may be available to us at a low cost Thus we will re-evaluate our choice when the samples are available
3 Polymorphisms in these and other genes interact with fruitantioxidant intake andor smoking to influence the risk of asthma and chronic bronchitis
Detailed Description:
There is suggestive evidence for a role of diet in the etiology of asthma and chronic bronchitis However there are few prospective data We propose to expand our collaboration with the Singapore Chinese Health Study to examine dietary environmental and genetic factors along with their interactions in relation to the risk of developing asthma and chronic bronchitis The Singapore Chinese Health Study NIH grant CA080205 is a cohort of 63257 men and women of Chinese ethnicity in Singapore who were aged 45-74 years at enrollment from 1993 to 1998 Telephone follow-up of the cohort to update and outcome information began in 1999 and is ongoing We expect to identify 538 cases of incident asthma and 672 cases of incident chronic bronchitis when the current follow-up questionnaire cycle is complete in 2004 In this proposal we would validate self-reports of incident asthma obtain follow-up data from the entire cohort to perform analyses of diet and smoking in relation to these outcomes and analyze genetic material on cases of incident asthma and chronic bronchitis and controls from the cohort In this proposal we will examine the following hypotheses
1 Higher intake of fruits andor antioxidant micronutrients decreases the risk of developing asthma and chronic bronchitis
a Effects of fruit andor antioxidant micronutrients may differ by smoking history
2 Common polymorphisms in genes involved in the response to oxidative stress influence the risk of asthma and chronic bronchitis We initially propose to examine polymorphisms in three genes -- glutathione S-tranferase M1 glutathione S-transferase P1 and matrix metalloproteinase-1 However we plan to examine additional relevant polymorphisms in the future especially taking advantage of high throughput screens of candidate genes for asthma and chronic bronchitis It is possible that by 2004 when the sample set will be available that more compelling candidates and high throughput screens may be available to us at a low cost Thus we will re-evaluate our choice when the samples are available
3 Polymorphisms in these and other genes interact with fruitantioxidant intake andor smoking to influence the risk of asthma and chronic bronchitis
1 Higher intake of fruits andor antioxidant micronutrients decreases the risk of developing asthma and chronic bronchitis
a Effects of fruit andor antioxidant micronutrients may differ by smoking history
2 Common polymorphisms in genes involved in the response to oxidative stress influence the risk of asthma and chronic bronchitis We initially propose to examine polymorphisms in three genes -- glutathione S-tranferase M1 glutathione S-transferase P1 and matrix metalloproteinase-1 However we plan to examine additional relevant polymorphisms in the future especially taking advantage of high throughput screens of candidate genes for asthma and chronic bronchitis It is possible that by 2004 when the sample set will be available that more compelling candidates and high throughput screens may be available to us at a low cost Thus we will re-evaluate our choice when the samples are available
3 Polymorphisms in these and other genes interact with fruitantioxidant intake andor smoking to influence the risk of asthma and chronic bronchitis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-E-N044 | None | None | None |