Ignite Creation Date:
2024-05-05 @ 4:54 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00330434
Status:
WITHDRAWN
Last Update Posted:
2020-11-10
First Post:
2006-05-25
Brief Title:
Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism
Sponsor:
Tufts University
Organization:
Tufts University
Study Overview
Official Title:
Human CYP2B6 Induction by Ethanol and Polymorphisms
Status:
WITHDRAWN
Status Verified Date:
2020-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Study was a F32 Fellowship Trial was proposed however Principle Investigator does not believe trial took place
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The two purposes of this study are
1 to determine what effect the chronic and moderateheavy drinking of alcoholic beverages has
1 on the blood level of bupropion and chlorzoxazone and their major breakdown products in the blood and
2 on the stimulant effect of bupropion and
2 to determine what effect a normal and common 25 frequency genetic variation of a specific liver enzyme that breaks down bupropion has
1 on the blood levels of bupropion and its major breakdown products in the blood and
2 on the stimulant effect of bupropion
Two groups of volunteers will be recruited for this study
1 volunteers who drink moderate to heavy amounts of alcohol frequently and
2 volunteers who usually do not drink alcohol
Volunteers will NOT be asked to change their drinking or nondrinking habits during the study
1 to determine what effect the chronic and moderateheavy drinking of alcoholic beverages has
1 on the blood level of bupropion and chlorzoxazone and their major breakdown products in the blood and
2 on the stimulant effect of bupropion and
2 to determine what effect a normal and common 25 frequency genetic variation of a specific liver enzyme that breaks down bupropion has
1 on the blood levels of bupropion and its major breakdown products in the blood and
2 on the stimulant effect of bupropion
Two groups of volunteers will be recruited for this study
1 volunteers who drink moderate to heavy amounts of alcohol frequently and
2 volunteers who usually do not drink alcohol
Volunteers will NOT be asked to change their drinking or nondrinking habits during the study
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1F32AA015647-01A1 | NIH | None | httpsreporternihgovquickSearch1F32AA015647-01A1 |
| F32AA015647-01A1 | NIH | None | None |