Ignite Creation Date:
2024-05-05 @ 11:08 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001663
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Treatment of Cortical Myoclonus With Repetitive Transcranial Magnetic Stimulation
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Treatment of Cortical Myoclonus With Repetitive Transcranial Magnetic Stimulation
Status:
COMPLETED
Status Verified Date:
2002-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Myoclonus is a condition related to epilepsy of involuntary twitching or jerking of the limbs
The purpose of this study is to determine if stimulation of the brain with magnetic pulses can decrease myoclonus Researchers believe that this may be possible because in studies on normal volunteers magnetic stimulation made areas of the brain difficult to activate for several minutes In addition early studies on patients with myoclonus have shown magnetic stimulation to be effective at decreasing involuntary movements
Transcranial Magnetic Stimulation TMS is a non-invasive technique that can be used to stimulate brain activity and gather information about brain function It is very useful when studying the areas of the brain and spinal cord related to motor activity motor cortex and corticospinal tract Repetitive transcranial magnetic stimulation rTMS involves the placement of coil of wire electromagnet on the patients scalp and rapidly turning on and off the electrical current The changing magnetic field produces weak electrical currents in the brain near the coil This permits non-invasive relatively localized stimulation of the surface of the brain cerebral cortex The effect of magnetic stimulation varies depending upon the location intensity and frequency of the magnetic pulses
Researchers plan to use rTMS for 10 days on patients participating in the study The 10 day period will be broken into 5 days of active repetitive magnetic stimulation and 5 days of placebo ineffective stimulation At the end of the 10 day period if the results show that rTMS was beneficial patients may undergo an additional 5 days of active rTMS
The purpose of this study is to determine if stimulation of the brain with magnetic pulses can decrease myoclonus Researchers believe that this may be possible because in studies on normal volunteers magnetic stimulation made areas of the brain difficult to activate for several minutes In addition early studies on patients with myoclonus have shown magnetic stimulation to be effective at decreasing involuntary movements
Transcranial Magnetic Stimulation TMS is a non-invasive technique that can be used to stimulate brain activity and gather information about brain function It is very useful when studying the areas of the brain and spinal cord related to motor activity motor cortex and corticospinal tract Repetitive transcranial magnetic stimulation rTMS involves the placement of coil of wire electromagnet on the patients scalp and rapidly turning on and off the electrical current The changing magnetic field produces weak electrical currents in the brain near the coil This permits non-invasive relatively localized stimulation of the surface of the brain cerebral cortex The effect of magnetic stimulation varies depending upon the location intensity and frequency of the magnetic pulses
Researchers plan to use rTMS for 10 days on patients participating in the study The 10 day period will be broken into 5 days of active repetitive magnetic stimulation and 5 days of placebo ineffective stimulation At the end of the 10 day period if the results show that rTMS was beneficial patients may undergo an additional 5 days of active rTMS
Detailed Description:
Repetitive transcranial magnetic stimulation rTMS at frequencies in the single Hz range causes a decrease in the excitability of the primary motor cortex and there is preliminary evidence that it can suppress abnormal excess cortical activity We plan to test 1 Hz rTMS as treatment for cortical myoclonus
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 97-N-0053 | None | None | None |