Ignite Creation Date:
2024-05-05 @ 4:54 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00338546
Status:
WITHDRAWN
Last Update Posted:
2019-01-16
First Post:
2006-06-16
Brief Title:
Study to Improve Scientific Understanding of the Cardiovascular Actions of Cocaine
Sponsor:
University of Texas Southwestern Medical Center
Organization:
University of Texas Southwestern Medical Center
Study Overview
Official Title:
Cocaine and Sympathetic Nerve Activity in Humans
Status:
WITHDRAWN
Status Verified Date:
2019-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to improve the scientific understanding of the cardiovascular actions of cocaine in particular the ability of cocaine to increase blood pressure
Detailed Description:
Cocaine abuse has emerged as a major cause of life-threatening cardiovascular emergencies but our understanding of the underlying mechanisms mediating the adverse effects of cocaine is far from complete Our previous studies in cocaine-naive human subjects have demonstrated that intranasal cocaine acutely stimulates the human cardiovascular system by a novel central mechanism of actionWe are currently investigating a central sympatholytic drugdexmedetomidine in reversing the sympathomimetic effects increase in blood pressure heart rate and coronary vasoconstriction of intranasal cocaineThis drug may be a new pharmacologic agent in the treatment of acute cocaine intoxication in humans
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None