Ignite Creation Date:
2024-05-05 @ 4:54 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00338065
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-04-23
First Post:
2006-06-15
Brief Title:
External Influences Upon Ocular Homeostasis
Sponsor:
Vanderbilt University Medical Center
Organization:
Vanderbilt University Medical Center
Study Overview
Official Title:
External Influences Upon Ocular Homeostasis
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Our experiments are designed to test the overall hypothesis that position-dependent or water-dependent intra-ocular pressure IOP spikes occur in humans and that these challenge ocular homeostasis
Detailed Description:
Glaucoma is the second leading cause of blindness in the United States yet its pathogenesis is poorly understood This is an insidious disorder since the loss of peripheral vision which occurs first usually is not noticed by the victim Approximately 1 million people in the United States have glaucoma but are not aware of it Glaucoma is not always associated with elevated intraocular pressures so that vision screenings which measure just intraocular pressure without assessing the optic nerve will also miss these patients with glaucomatous damage Therefore patients are often diagnosed only when they have severe irreversible vision loss Vascular insufficiency or abnormal autoregulation versus mechanical pressure damage has been proposed as a major factor in the development of glaucoma Presently therapy is based upon lowering intraocular pressure If a contributing intermittent pressure elevation factor can be elucidated and characterized specific treatment modalities may then be developed and their effectiveness can be monitored
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None