Ignite Creation Date:
2024-05-06 @ 12:49 PM
Last Modification Date:
2024-10-26 @ 1:04 PM
Study NCT ID:
NCT03852368
Status:
WITHDRAWN
Last Update Posted:
2021-02-12
First Post:
2019-02-21
Brief Title:
The Effects of Exercise on Executive Functions
Sponsor:
University of California Irvine
Organization:
University of California Irvine
Study Overview
Official Title:
UC Reliance 3107 Exercise and the Brain Measuring Executive Functions During and Following an Acute Bout of Aerobic Exercise
Status:
WITHDRAWN
Status Verified Date:
2021-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Nonapplicable clinical trial
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this research is to develop an assessment protocol that can be used to study the effect of different intensities of exercise on executive functions EF attention working memory inhibition and cognitive flexibility It has been shown that exercise has the potential to improve the development of EF in healthy and special needs children However many exercise interventions in the literature lack rigorous control of critical components such as intensity making it difficult to draw conclusions about what type and how much exercise might be most beneficial for EF In addition to date no studies have been able to demonstrate the engagement of EF during exercise This study will focus on developing an assay that measures important self-regulation or EF sub-processes eg attention and inhibitory control as well as examining engagement of these targets during different exercise intensities Participants will exercise in different intensities on a cycle ergometer and perform cognitive assessments before during and after exercise to evaluate EF This research will allow us to develop an assessment protocol that can be used in future research to understand the underlying mechanisms underpinning the effects of exercise on EF
Detailed Description:
Self-regulation self-control and executive functioning are umbrella constructs that encompass processes involved in exerting control over cognitive and behavioral processes Self-regulation was described as an ability reflecting mature cognition Mature cognition is characterized by abilities that include being able a to hold information in mind including complicated representational structures to mentally manipulate that information and to act on the basis of it b to act on the basis of choice rather than impulse exercising self-control or self-regulation by resisting inappropriate behaviors and responding appropriately and c to quickly and flexibly adapt behavior to changing situations These abilities are referred to respectively as working memory inhibition and cognitive flexibility Together they are key components of both cognitive control and executive functions Some researchers have proposed an integrative framework of self-regulation than encompasses executive functions and self-control Thus in this proposal we have adopted such an integrative framework whereby self-regulation encompasses executive functions self-control and other sub-processes As noted in the specific aims our meta-analysis and narrative review examining the impact of 28 physical activity PA and exercise interventions on EF outcomes in healthy children reported that the targets often shown to improve after exercise were attention working memory inhibition and cognitive flexibility and preliminary research suggests the strongest effects are on attention and inhibition The goal of this project is to develop an assay to examine engagement of attention and inhibitory control across several rigorously controlled exercise conditions This proposal is built on an integrative framework whereby self-regulation encompasses executive functions EF self-control and other sub-processes Although there is a growing awareness of the benefits of exercise on self-regulatory processes in children including EF there are still many critical gaps in the research A recent publication which is a meta-analysis and narrative review examining the impact of 28 physical activity and exercise interventions on EF outcomes in healthy children that highlights some of these gaps Although earlier results showed that interventions had a significant small to moderate positive effect on EF the effects varied widely across studies This research informed this application in several ways First no study demonstrated how or why the interventions improved EF outcomes Additionally the behavioral assays or measures varied widely targeting numerous components of EF The EF targets most often shown to improve after exercise were attention working memory inhibition and cognitive flexibility each improved in at least five of the included studies These findings are consistent with recent work at the UC Irvine Pediatric Exercise and Genomics Research Center PERC in studies with healthy children and children with special needs improvements were found after exercise in all four components Few if any studies have been able to demonstrate empirically why participants exhibit improvements in EF after exercise and studies have not yet demonstrated engagement of EF during exercise Thus there is a need to understand why exercise seems to improve these targets However the tools used in exercise research to date are limited Many have been adopted from developmental or educational research rather than developed specifically to test targets in exercise research our search yielded only one published measure of self-regulation cognitive affective and motor self-regulation that has been administered during physical activity This proposal begins to address these gaps in the literature by focusing on the development of an assay for important EF targets are improved through exercise and by testing engagement of these targets during exercise of varying intensity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None