Ignite Creation Date:
2024-05-05 @ 4:53 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00336401
Status:
COMPLETED
Last Update Posted:
2010-07-30
First Post:
2006-06-08
Brief Title:
Peri-Operative And Long-Term Cardioprotective Properties Of Sevoflurane In High Risk Patients Undergoing Non-Cardiac Surgery
Sponsor:
University Health Network Toronto
Organization:
University Health Network Toronto
Study Overview
Official Title:
Peri-Operative And Long-Term Cardioprotective Properties Of Sevoflurane In High Risk Patients Undergoing Non-Cardiac Surgery
Status:
COMPLETED
Status Verified Date:
2006-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Non-cardiac surgery is associated with significant cardiac morbidity and mortality Volatile anesthetics have a cardioprotective effects which results in preservation of left ventricular function and lower troponin I levels Lower troponin release has been correlated with better long term event free survival in both cardiac and non cardiac surgery A recently completed meta-analysis suggests that sevoflurane is a superior volatile agent The evidence of a cardioprotective effect in non-cardiac surgery is lacking Base on the current literature we intend to evaluate the protective potential of sevoflurane versus propofol anesthesia in high risk patients undergoing elective non-cardiac procedures
Hypothesis The use of Sevoflurane as a general anesthetic reduces postoperative troponin release the incidence of myocardial infarction andor long term morbidity in patients at low to moderate risk of postoperative cardiac complications who are undergoing noncardiac surgery
Hypothesis The use of Sevoflurane as a general anesthetic reduces postoperative troponin release the incidence of myocardial infarction andor long term morbidity in patients at low to moderate risk of postoperative cardiac complications who are undergoing noncardiac surgery
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None