Ignite Creation Date:
2024-05-06 @ 12:47 PM
Last Modification Date:
2024-10-26 @ 1:04 PM
Study NCT ID:
NCT03846245
Status:
COMPLETED
Last Update Posted:
2021-06-09
First Post:
2019-02-18
Brief Title:
Cross-sectional Study for the Identification of Blood Biomarkers in Healthy Young and Old Individuals
Sponsor:
Barcelonabeta Brain Research Center Pasqual Maragall Foundation
Organization:
Barcelonabeta Brain Research Center Pasqual Maragall Foundation
Study Overview
Official Title:
AlfaAge Cross-sectional Study for the Identification of Blood Biomarkers in Healthy Young and Old Individuals
Status:
COMPLETED
Status Verified Date:
2021-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AlfaAge
Brief Summary:
Ageing is clearly the most important risk factor for AD and other dementias but despite the amount of evidence supporting this fact the exact mechanism that link ageing and AD is still unknown and up to now potential therapies for AD by targeting ageing have been poorly explored This study aims to provide a better understanding of the link between ageing and AD by means of measuring in human blood those factors that have been found to be pro-youthful GDF-11 CSF2 TIMP-2 oxytocin or pro-aging CCL2 CCL11 CCL19 Haptoglobine B2-microglobuline in experimental animal models but have not been comprehensively studied in humans
In this proof-of-concept study these blood factors in extreme groups of age namely young adults 18-25 yo and old adults 70 yo will be measured and the hypothesis of whether the pro-youthful and pro-ageing blood factors change throughout age tested In order to include a wider range of age human umbilical cord blood and plasma from teenagers which is already available from a previous study will also be included
The ultimate goal of this study is to select the more promising blood factors and obtain data on the effect size of the differences that may allow us in the future to design a larger study
In this proof-of-concept study these blood factors in extreme groups of age namely young adults 18-25 yo and old adults 70 yo will be measured and the hypothesis of whether the pro-youthful and pro-ageing blood factors change throughout age tested In order to include a wider range of age human umbilical cord blood and plasma from teenagers which is already available from a previous study will also be included
The ultimate goal of this study is to select the more promising blood factors and obtain data on the effect size of the differences that may allow us in the future to design a larger study
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None