Ignite Creation Date:
2024-05-06 @ 12:47 PM
Last Modification Date:
2024-10-26 @ 1:04 PM
Study NCT ID:
NCT03849963
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-02-28
First Post:
2019-02-14
Brief Title:
Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain
Sponsor:
University of Texas Southwestern Medical Center
Organization:
University of Texas Southwestern Medical Center
Study Overview
Official Title:
Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HP Brain
Brief Summary:
Investigators propose to develop hyperpolarized 13C-labeled pyruvate as potential imaging probes to assess two essential in vivo processes in cerebral metabolism oxidative metabolism and synthesis of a neurotransmitter in this observational study
Detailed Description:
Investigators will perform a pilot study to test the translational feasibility by evaluating sensitivity and repeatability of hyperpolarized 1-13Cpyruvate and 2-13Cpyruvate in healthy human subjects n 10 each Each subject will be imaged twice using the same hyperpolarized substrate with an interval 45min between the injections to evaluate repeatability Finally eight subjects will be imaged with both hyperpolarized 1-13Cpyruvate and 2-13Cpyruvate for comparison
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None