Ignite Creation Date:
2024-05-05 @ 4:53 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00330941
Status:
COMPLETED
Last Update Posted:
2023-04-13
First Post:
2006-05-25
Brief Title:
Intravenous Lidocaine and Acute Rehabilitation
Sponsor:
The Cleveland Clinic
Organization:
The Cleveland Clinic
Study Overview
Official Title:
Intravenous Lidocaine Infusion Improves Outcome After Laparoscopic Colectomy
Status:
COMPLETED
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background Intravenous infusion of lidocaine may decrease postoperative pain and speed return of bowel function The investigators therefore tested the hypothesis that including perioperative lidocaine infusion improves recovery from laparoscopic colectomy and shortens the duration of hospitalization
Methods Forty patients scheduled for laparoscopic colectomy were randomly allocated to receive intravenous lidocaine bolus injection of 15 mgkg-1 lidocaine at induction of anesthesia then a continuous infusion of 2 mgkg-1h-1 intraoperatively and 133 mgkg-1h-1 for 24 h postoperatively or an equal volume of saline All patients received similar intensive postoperative rehabilitation Postoperative pain scores opioid consumption and fatigue scores were measured Times to first flatus defecation and hospital discharge were recorded Postoperative endocrine cortisol and catecholamines and metabolic leucocytes C-reactive protein and glucose responses were measured for 48 h Data median 25-75 interquartile range Saline vs Lidocaine groups were analyzed using Mann-Whitney tests P005 was considered statistically significant
Methods Forty patients scheduled for laparoscopic colectomy were randomly allocated to receive intravenous lidocaine bolus injection of 15 mgkg-1 lidocaine at induction of anesthesia then a continuous infusion of 2 mgkg-1h-1 intraoperatively and 133 mgkg-1h-1 for 24 h postoperatively or an equal volume of saline All patients received similar intensive postoperative rehabilitation Postoperative pain scores opioid consumption and fatigue scores were measured Times to first flatus defecation and hospital discharge were recorded Postoperative endocrine cortisol and catecholamines and metabolic leucocytes C-reactive protein and glucose responses were measured for 48 h Data median 25-75 interquartile range Saline vs Lidocaine groups were analyzed using Mann-Whitney tests P005 was considered statistically significant
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None