Ignite Creation Date:
2024-05-06 @ 12:46 PM
Last Modification Date:
2024-10-26 @ 1:03 PM
Study NCT ID:
NCT03841474
Status:
UNKNOWN
Last Update Posted:
2021-02-18
First Post:
2019-01-13
Brief Title:
The Recovery of Cardiovascular Patients With Depression
Sponsor:
Klinički Bolnički Centar Zagreb
Organization:
Klinički Bolnički Centar Zagreb
Study Overview
Official Title:
The Changes in Functional Recovery and Brain Neurotrophic Factor Six Months After Percutaneous Coronary Intervention in Cardiovascular Patients With Depression
Status:
UNKNOWN
Status Verified Date:
2021-02
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Cardiovascular disease increases the risk of depression and vice versa Many cardiovascular patients are subjected to percutaneous coronary intervention PCI Potential biomarkers for the development the course and the recovery of both diseases are in the focus of interest of many studies One of the biomarkers that stands out is brain derived neurotrophic factor BDFN BDNF plays a significant role in regulating vascular growth and repair but also stimulates the survival differentiation and conservation of neurons
The aim of the study is to detect the depression in patients undergoing PCI and to determine the impact of psychiatric treatment on the functional recovery and on the changes of BDNF
The aim of the study is to detect the depression in patients undergoing PCI and to determine the impact of psychiatric treatment on the functional recovery and on the changes of BDNF
Detailed Description:
It has been shown that cardiovascular disease increases the risk of depression and vice versa A significant proportion of cardiovascular diseases are coronary artery disease most of these patients are subjected to percutaneous coronary intervention PCI That population of patients which is under greater risk of depression has been passing through the health system without adequate management of psychiatric difficulties Despite the abundance of the data regarding the concomitancy of cardiovascular disease and depression potential biomarkers for the development the course and the recovery of both diseases are still in the focus of interest of many studies One of the biomarkers that stands out is brain derived neurotrophic factor BDFN BDNF plays a significant role in regulating vascular growth and repair but also stimulates the survival differentiation and conservation of neurons Its serum level is reduced in cardiac failure and acute coronary syndrome and indicates a higher risk of coronary incident in angina pectoris BDNF is also reduced in depression but increases during a pharmacological treatment along with the clinical improvement
Therefore the aim of the study is to detect the occurrence of depression in patients undergoing PCI and to determine the impact of psychiatric treatment on the functional recovery of those patient and the correlation with the changes of serum levels of BDNF
This represents the objectivization of the tertiary type of prevention intervention for recovery of cardiovascular patients who are currently passing through the investigators health system with unrecognized psychiatric comorbidity
Therefore the aim of the study is to detect the occurrence of depression in patients undergoing PCI and to determine the impact of psychiatric treatment on the functional recovery of those patient and the correlation with the changes of serum levels of BDNF
This represents the objectivization of the tertiary type of prevention intervention for recovery of cardiovascular patients who are currently passing through the investigators health system with unrecognized psychiatric comorbidity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None