Ignite Creation Date:
2024-05-05 @ 4:53 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00333320
Status:
COMPLETED
Last Update Posted:
2012-10-23
First Post:
2006-06-02
Brief Title:
Positive Effect of Ischemic Postconditioning During Acute Myocardial Infarction
Sponsor:
French Cardiology Society
Organization:
French Cardiology Society
Study Overview
Official Title:
Positive Effect of Ischemic Postconditioning During Acute Myocardial Infarction
Status:
COMPLETED
Status Verified Date:
2012-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine whether brief periods of ischemia performed just at the time of reperfusion -postconditioning- can reduce coronary endothelial dysfunction and infarct size in humans
Detailed Description:
Desobstruction of the culprit artery after acute myocardial infarction allows to reduce the consequences of prolonged ischemia However it is now clearly established that reperfusion induces by itself severe myocardial injuries Postconditioning has been described as an adaptive response triggered by a brief ischemia applied after a prolonged coronary occlusion Several teams have reported that ischemiareperfusion cycles allow to reduce infarct size in experimental models
Different pathophysiological processes have been proposed to explain the beneficial effect of postconditioning It has been reported that postconditioning reduces the inflammatory response and activates cardioprotective signaling pathways Akt eNOS p70S6K In addition an improvement of the endothelial function has been reported
This controlled trial aim to study the potential beneficial effect of postconditioning in patients with acute myocardial infarction Forty six patients will be included in the study and the culprit artery will be reoccluded three times for 1 minutes after desobstruction in one of the both groups after randomization of the patients
The evaluation will be focused on the comparison of the coronary reserve after intracoronary adenosine injection In addition additional parameters will be used to study the effect of postconditioning on post-ischemic endothelial dysfunction frequencies of low reflow and slow reflow situation myocardial blush and regression of ST elevation The effect of postconditioning on the left ventricular systolic function will be studied by Doppler tissue imaging and RMN
Different pathophysiological processes have been proposed to explain the beneficial effect of postconditioning It has been reported that postconditioning reduces the inflammatory response and activates cardioprotective signaling pathways Akt eNOS p70S6K In addition an improvement of the endothelial function has been reported
This controlled trial aim to study the potential beneficial effect of postconditioning in patients with acute myocardial infarction Forty six patients will be included in the study and the culprit artery will be reoccluded three times for 1 minutes after desobstruction in one of the both groups after randomization of the patients
The evaluation will be focused on the comparison of the coronary reserve after intracoronary adenosine injection In addition additional parameters will be used to study the effect of postconditioning on post-ischemic endothelial dysfunction frequencies of low reflow and slow reflow situation myocardial blush and regression of ST elevation The effect of postconditioning on the left ventricular systolic function will be studied by Doppler tissue imaging and RMN
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| SFC-2006-02 | None | None | None |