Ignite Creation Date:
2024-05-06 @ 12:45 PM
Last Modification Date:
2024-10-26 @ 1:03 PM
Study NCT ID:
NCT03830138
Status:
UNKNOWN
Last Update Posted:
2019-02-05
First Post:
2019-02-01
Brief Title:
Oxidized LDL With Oxygen Therapy in Acute Coronary Syndrome
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Oxidized LDL Oxidized LDL Receptor 1 OLR1 Gene Polymorphism With Oxygen Therapy in Acute Myocardial Infarction
Status:
UNKNOWN
Status Verified Date:
2019-02
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Coronary artery disease CAD is increasing rapidly in Egyptian people and manifesting a younger age Higher plasma low-density lipoprotein cholesterol LDL-C is a major predictor for the development of CAD However whether oxidized-LDL ox-LDL can be used as a risk factor for myocardial infarction MI has not been fully investigated Therefore the aim of the present study was to examine the role of ox-LDL as a risk factor for the presence and clinical outcomes in patients with MI
Detailed Description:
Cardiovascular disease which is multifactorial and caused by complex interactions of genetic and environmental factors represents the main cause of death all over the world Traditional risk factors for coronary atherosclerosis include age smoking male gender hypertension and diabetes Newly defined risk factors such as hyper-homocysteine elevated plasma levels of OxLDL and oxidative stress are also emerging
Lectin-like oxidized low-density lipoprotein receptor-1 LOX-1 is the major receptor of oxidized low-density lipoproteins which regulates the growth of a variety of cells and is important in inflammation atherosclerosis oxidative stress and tissue remodeling LOX-1 is expressed in various cells including endothelial cells macrophages and chondrocytes and its expression is enhanced by proinflammatory cytokines The LOX1 gene also known as OLR1 is located on the chromosome 12p131-p123 The LOX1 protein is synthesized as a 40-kDa precursor protein and is composed of four domains an extracellular lectin-like domain at the C-terminal a connecting neck domain a transmembrane domain and an N-terminal cytoplasmic domain Three single nucleotide polymorphism SNPs namely intron 4 GA intron 5TG and 3 UTR TC in the LOX1 gene have been previously reported These polymorphisms have also been associated with CAD
Oxygen is a lifesaving drug Giving oxygen to a patient with an impending clinical emergency has become knee-jerk reflex reaction of the clinician Patient with AMI has compromised myocardial perfusion and event arises due to myocardial hypoxia It appears quite logical and biologically plausible to give oxygen in such situations to improve the oxygenation of the ischemic myocardial tissue and decrease ischemic pain On the other side oxygen may be harmful with a mechanism such as the paradoxical effect of oxygen in decreasing coronary artery blood flow and increasing coronary vascular resistance due to increased oxygen free radicals The investigators aimed to examine the association of the OLR1 gene with AMI or CAD in a novel well-phenotyped and homogenous population and its correlation with oxygen therapy in these patients
Lectin-like oxidized low-density lipoprotein receptor-1 LOX-1 is the major receptor of oxidized low-density lipoproteins which regulates the growth of a variety of cells and is important in inflammation atherosclerosis oxidative stress and tissue remodeling LOX-1 is expressed in various cells including endothelial cells macrophages and chondrocytes and its expression is enhanced by proinflammatory cytokines The LOX1 gene also known as OLR1 is located on the chromosome 12p131-p123 The LOX1 protein is synthesized as a 40-kDa precursor protein and is composed of four domains an extracellular lectin-like domain at the C-terminal a connecting neck domain a transmembrane domain and an N-terminal cytoplasmic domain Three single nucleotide polymorphism SNPs namely intron 4 GA intron 5TG and 3 UTR TC in the LOX1 gene have been previously reported These polymorphisms have also been associated with CAD
Oxygen is a lifesaving drug Giving oxygen to a patient with an impending clinical emergency has become knee-jerk reflex reaction of the clinician Patient with AMI has compromised myocardial perfusion and event arises due to myocardial hypoxia It appears quite logical and biologically plausible to give oxygen in such situations to improve the oxygenation of the ischemic myocardial tissue and decrease ischemic pain On the other side oxygen may be harmful with a mechanism such as the paradoxical effect of oxygen in decreasing coronary artery blood flow and increasing coronary vascular resistance due to increased oxygen free radicals The investigators aimed to examine the association of the OLR1 gene with AMI or CAD in a novel well-phenotyped and homogenous population and its correlation with oxygen therapy in these patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None