Ignite Creation Date:
2024-05-05 @ 4:53 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00331812
Status:
UNKNOWN
Last Update Posted:
2011-01-19
First Post:
2006-05-23
Brief Title:
Mitochondrial Functions and Oxidative Stress in ALS Patients
Sponsor:
University Hospital Clermont-Ferrand
Organization:
University Hospital Clermont-Ferrand
Study Overview
Official Title:
Study of Mitochondrial Functions and Oxidative Stress in ALS Patients
Status:
UNKNOWN
Status Verified Date:
2011-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In Amyotrophic Lateral Sclerosis ALS malnutrition is frequent 16 to 50 of the patients and is an independent prognostic factor One of the implicated factors is the increase of resting energy expenditure REE which can be found in about 50 of ALS patients The origin of this hypermetabolism is currently unknown but could be located in the mitochondria In fact some studies have found mitochondrial abnormalities and the existence of an oxidative stress Thus the aim of this study is to characterize the mitochondrial abnormalities and the oxidantantioxidant status of ALS patients and to determine their relationship with the metabolic status hypermetabolism or normometabolism Three groups of patients will be studied 20 hypermetabolic ALS patients 20 normometabolic ALS patients and 20 healthy volunteers paired for age and sex
Detailed Description:
In Amyotrophic Lateral Sclerosis ALS malnutrition is frequent 16 to 50 of the patients and is an independent prognostic factor One of the implicated factors is the increase of resting energy expenditure REE which can be found in about 50 of ALS patients The origin of this hypermetabolism is currently unknown but could be located in the mitochondria In fact some studies have found mitochondrial abnormalities and the existence of an oxidative stress Thus the aim of this study is to characterize the mitochondrial abnormalities and the oxidantantioxidant status of ALS patients and to determine their relationship with the metabolic status hypermetabolism or normometabolism Three groups of patients will be studied 20 hypermetabolic ALS patients 20 normometabolic ALS patients and 20 healthy volunteers paired for age and sex
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None