Ignite Creation Date:
2024-05-05 @ 4:53 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00339976
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2006-06-19
Brief Title:
Exposure to Neurotoxins as Risk Factors for Amyotrophic Lateral Sclerosis
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Ascertainment of Death in ALS Patients
Status:
COMPLETED
Status Verified Date:
2008-04-21
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is a follow-up to an earlier study that examined the relationship of This study will examine whether exposure to neurotoxins such as lead mercury solvents and pesticides can contribute to amyotrophic lateral sclerosis ALS also known as Lou Gehrigs disease The cause of this degenerative disease of the brain and spinal cord is not well understood Some studies suggest that exposure to environmental neurotoxins may increase its risk This follow-up study will examine the relationship of neurotoxin exposure to the interval between the diagnosis of ALS and death It will also examine the possible roles of genetics lifestyle and dietary factors in the disease Information on ALS patients previously enrolled in the study will be used to examine this relationship No new individuals will be enrolled in the study
Detailed Description:
Objective The objective of this proposal is linkage with the National Death Index NDI for cases from a study that was conducted in the early 1990s The purpose of the initial study was to examine the role that lead and other exposures including mercury and solvents play in the etiology of amyotrophic lateral sclerosis ALS
Study population The study involved 110 ALS cases and 256 population based controls recruited in New England between 1993 and 1996 Data collection involved an interview blood collection and measurement of bone lead using x-ray fluorescence
Design and outcome parameters The results of this study suggested that lead exposure was a risk factor for ALS Compared to controls cases were more likely to have occupational lead exposure and both blood and bone lead levels were higher in cases We are presently analyzing data on other neurotoxic exposures including mercury solvents and pesticides In order to investigate prognosis we would like to determine the date of death by searching the National Death Index This information will enable us to evaluate the relationship of neurotoxic exposures to ALS prognosis
Study population The study involved 110 ALS cases and 256 population based controls recruited in New England between 1993 and 1996 Data collection involved an interview blood collection and measurement of bone lead using x-ray fluorescence
Design and outcome parameters The results of this study suggested that lead exposure was a risk factor for ALS Compared to controls cases were more likely to have occupational lead exposure and both blood and bone lead levels were higher in cases We are presently analyzing data on other neurotoxic exposures including mercury solvents and pesticides In order to investigate prognosis we would like to determine the date of death by searching the National Death Index This information will enable us to evaluate the relationship of neurotoxic exposures to ALS prognosis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-E-N275 | None | None | None |