Ignite Creation Date:
2024-05-05 @ 11:08 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001675
Status:
COMPLETED
Last Update Posted:
2019-12-09
First Post:
1999-11-03
Brief Title:
The Effect of Positive and Negative Emotions on Brain Activity in Alcoholics and Nonalcoholics
Sponsor:
National Institute on Alcohol Abuse and Alcoholism NIAAA
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Functional Neuroanatomy of Positive and Negative Affect in Alcoholics and Non-Alcoholics
Status:
COMPLETED
Status Verified Date:
2015-12-23
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study was designed to learn more about the areas of the brain involved in the experience of positive and negative emotions
Patients who would like to participate in this study will first undergo a screening process to see if they will be eligible for the study Patients eligible to participate in the study will go through two sessions
During session one researchers will attempt to evoke positive and negative emotions by showing patients slides of different emotion-arousing stimuli pictures of pleasant and unpleasant scenes While patients are viewing these slides researchers will be measuring patients heart rate sweating and eye-blinking
During session two patients will undergo an MRI of the brain while seeing similar emotion-arousing pictures as in session one In addition patients may be asked to play a simple computer game for a reward of money while researchers use the MRI to measure brain activity
Researchers hope to develop methods to evoke positive and negative emotions and simultaneously at the same time see brain activation in normal volunteers alcoholics and recovered alcoholicsTAB
Patients who would like to participate in this study will first undergo a screening process to see if they will be eligible for the study Patients eligible to participate in the study will go through two sessions
During session one researchers will attempt to evoke positive and negative emotions by showing patients slides of different emotion-arousing stimuli pictures of pleasant and unpleasant scenes While patients are viewing these slides researchers will be measuring patients heart rate sweating and eye-blinking
During session two patients will undergo an MRI of the brain while seeing similar emotion-arousing pictures as in session one In addition patients may be asked to play a simple computer game for a reward of money while researchers use the MRI to measure brain activity
Researchers hope to develop methods to evoke positive and negative emotions and simultaneously at the same time see brain activation in normal volunteers alcoholics and recovered alcoholicsTAB
Detailed Description:
Objective The purpose of this protocol is two-fold 1 to determine how individual differences in evoked brain responses relate to generalized trait personality and behavior differences as assessed by psychometric questionnaire instruments and behavioral measures and 2 to determine whether individual differences in evoked brain responses relate specifically to genetic polymorphisms in genes governing neurotransmitter activity
Study population Healthy non-alcoholic adult volunteers healthy adolescents aged 12 to 17 years with or without a family history of alcohol use disorder inpatient or outpatient alcoholics and recovering alcoholics
Design In this event-related functional magnetic resonance imaging fMRI study we will attempt to evoke positive and negative affect via several different standardized methods including 1 pictures of emotion-arousing stimuli 2 pictures of emotional facial expression 3 cues signaling reward or punishment This protocol is designed to cover many different functional magnetic imaging studies all using similar techniques to evoke and measure positive and negative affect in the brain Most subjects will not participate in studies involving all the methods described in the protocol
Outcome measures The outcome measure is differences in blood oxygenation dependent level BOLD signal measured using standard fMRI techniques and analyzed using AFNI software
Study population Healthy non-alcoholic adult volunteers healthy adolescents aged 12 to 17 years with or without a family history of alcohol use disorder inpatient or outpatient alcoholics and recovering alcoholics
Design In this event-related functional magnetic resonance imaging fMRI study we will attempt to evoke positive and negative affect via several different standardized methods including 1 pictures of emotion-arousing stimuli 2 pictures of emotional facial expression 3 cues signaling reward or punishment This protocol is designed to cover many different functional magnetic imaging studies all using similar techniques to evoke and measure positive and negative affect in the brain Most subjects will not participate in studies involving all the methods described in the protocol
Outcome measures The outcome measure is differences in blood oxygenation dependent level BOLD signal measured using standard fMRI techniques and analyzed using AFNI software
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 98-AA-0056 | None | None | None |