Ignite Creation Date:
2024-05-06 @ 12:42 PM
Last Modification Date:
2024-10-26 @ 1:03 PM
Study NCT ID:
NCT03829605
Status:
UNKNOWN
Last Update Posted:
2019-02-04
First Post:
2019-02-01
Brief Title:
Plasma Hydrogen Sulfide Nitric Oxide and Stress Hyperglycemia in Acute Myocardial Infarction
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Plasma Measurement of Hydrogen Sulfide Nitric Oxide and Stress Hyperglycemia in Acute Myocardial Infarction
Status:
UNKNOWN
Status Verified Date:
2019-02
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute myocardial infarction AMI can cause heart failure an irregular heartbeat cardiogenic shock or cardiac arrest It is the major cause of morbidity and mortality in the general population The diagnosis of AMI is complex basing on the clinical history physical examination cardiac markers and a chest radiograph Besides considering that the mechanisms linking activation of inflammation and ACS are complex as well progress in diagnosis and therapy improves little
Detailed Description:
The World Health Organization WHO indexed cardiovascular disease CVD as a leading foundation for human death in developing as well as developed countries Ischemic necrosis of the myocardium is called myocardial infarction Despite improvements in medical and interventional therapies in recent years acute myocardial infarction is still an important cause of mortality and morbidity Hydrogen sulfide H2S is a colorless water-soluble gas and is an endogenously produced labile diffusible mediator with multiple roles in the cardiovascular system in health and disease H2S is endogenously generated and cystathionine-β-synthase CBS cystathionine-γ-lyase CSE and 3-mercaptopyruvate sulfurtransferase 3-MST are key enzymes involved in its biological production Once interacting with carbon monoxide and nitric oxide H2S will initiate a unique gaseous signaling network and participate in the regulation of multiple pathophysiological processes Plasma H2S levels negatively correlated with HbA1c duration of diabetes and systolic and diastolic blood pressures
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None