Ignite Creation Date:
2024-05-06 @ 12:41 PM
Last Modification Date:
2024-10-26 @ 1:02 PM
Study NCT ID:
NCT03822910
Status:
COMPLETED
Last Update Posted:
2024-04-30
First Post:
2019-01-23
Brief Title:
Hippocampal Memory Circuits in Delusions
Sponsor:
NYU Langone Health
Organization:
NYU Langone Health
Study Overview
Official Title:
Hippocampal Memory Circuits in Delusions
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will investigate dentate gyrus DG and hippocampal CA3 sub field function using the pattern separation paradigm as reflected by the difference in brain activation in response to same-as-previously- seen OLD vs similar-to-previously-seen SIM objects in first episode psychosis FEP subjects before and after anti psychotic treatment and in matched healthy controls HC The current study uses three novel high-resolution task-based and post-encoding resting fMRI measures to probe hippocampal circuitry in delusions It will also study CA1 function using a sequential associative mismatch paradigm as reflected by activation of CA1 in response to mismatching information compared to memory of that stimulus in FEP subjects before and after antipsychotic treatment and in matched HC Finally this study will evaluate plasticity of hippocampal intrinsic functional connectivity IFC in response to memory consolidation using an encoding-plasticity paradigm in FEP subjects before and after anti psychotic treatment and in matched HC For each of the three imaging projects a total of 50 FEP subjects and 50 matched healthy controls HC will be studied hence 300 subjects will be studied over 5 years Within each paradigm medication-naive FEP subjects will be studied at baseline and 8 weeks after starting anti psychotic medication HC participants will be studied at baseline and 8 weeks later but will not receive any treatment
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None