Ignite Creation Date:
2024-05-06 @ 12:40 PM
Last Modification Date:
2024-10-26 @ 1:02 PM
Study NCT ID:
NCT03823612
Status:
UNKNOWN
Last Update Posted:
2019-01-30
First Post:
2019-01-28
Brief Title:
Reminerlization Potential of Innovative Biomimetic Material in Caries White Spot Lesions
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
Reminerlization Potential of Innovative Biomimetic Material Versus Casein Phosphopeptide-amorphous Calcium Phosphate in Caries White Spot Lesions A Randomized Clinical Trial
Status:
UNKNOWN
Status Verified Date:
2019-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
to remineralize the white spot caries lesions after orthodontic treatment the investigator will use two different materials Clinpro tooth creme versus Gc tooth mousse and will compare between their effects in remineralization of white spot caries lesions
Detailed Description:
Dental caries is the localized destruction of tooth tissues by acids especially lactic acid produced by the fermentation of dietary carbohydrates by bacteria in dental plaque Demineralization can be arrested or reversed when remineralization agents are applied to incipient carious or non-cavitated carious lesions A large number of therapeutic agents including non-fluoridated products have been developed to promote enamel remineralization The process of restoring lost mineral ions to the tooth structure and strengthening the lattice work is known as remineralization
The development of decalcification around orthodontic brackets and bands commonly called white spot lesions WSLs is often observed in patients with poor oral hygiene during treatment In many instances these WSLs continue to be visible after the removal of fixed appliances and after natural remineralization The remineralized enamel crystallites are generally more resistant to decalcification and also have the same orientation as the original enamel crystallites The early enamel lesions have a potential for remineralization with an increased resistance to further acid challenge particularly with the use of enhanced remineralization treatments
Recaldent is derived from the milk protein casein For many years it has been known that milk and its derivatives have a tooth protective effect Research has shown that this activity is due to a part of the casein protein called Casein Phosphopeptide or CPP which carries calcium and phosphate ions in the form of Amorphous Calcium Phosphate or ACP which used in reminerlization of white spot caries lesions
Clinpro tooth crème 3M ESPE is a 021 ww sodium fluoride NaF anti caries dentifrice that contains 950 ppm fluoride and a functionalized tricalcium phosphate f-TCP ingredientOne major advantage of this calcium phosphate system is that it is stable in aqueous environment and also does not affect the fluoride activity added in the dentifrices Furthermoreit has been suggested that fluoride combination with f-TCP not only provides greater remineralization in terms of microhardness and fluoride uptake but also decreases the dose of fluoride required to achieve the same degree of remineralization
The development of decalcification around orthodontic brackets and bands commonly called white spot lesions WSLs is often observed in patients with poor oral hygiene during treatment In many instances these WSLs continue to be visible after the removal of fixed appliances and after natural remineralization The remineralized enamel crystallites are generally more resistant to decalcification and also have the same orientation as the original enamel crystallites The early enamel lesions have a potential for remineralization with an increased resistance to further acid challenge particularly with the use of enhanced remineralization treatments
Recaldent is derived from the milk protein casein For many years it has been known that milk and its derivatives have a tooth protective effect Research has shown that this activity is due to a part of the casein protein called Casein Phosphopeptide or CPP which carries calcium and phosphate ions in the form of Amorphous Calcium Phosphate or ACP which used in reminerlization of white spot caries lesions
Clinpro tooth crème 3M ESPE is a 021 ww sodium fluoride NaF anti caries dentifrice that contains 950 ppm fluoride and a functionalized tricalcium phosphate f-TCP ingredientOne major advantage of this calcium phosphate system is that it is stable in aqueous environment and also does not affect the fluoride activity added in the dentifrices Furthermoreit has been suggested that fluoride combination with f-TCP not only provides greater remineralization in terms of microhardness and fluoride uptake but also decreases the dose of fluoride required to achieve the same degree of remineralization
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None