Ignite Creation Date:
2024-05-05 @ 4:53 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00339534
Status:
COMPLETED
Last Update Posted:
2020-05-20
First Post:
2006-06-19
Brief Title:
Survey of Prostate Cancer in Accra Ghana
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Survey of Prostate Cancer in Accra Ghana
Status:
COMPLETED
Status Verified Date:
2020-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study conducted at Korle-Bu Hospital in Accra Ghana will help elucidate the roles of lifestyle and genetic factors in prostate cancer risk There is a strong variation in risk of prostate cancer throughout the world The rates of the disease among African Americans are some of the world s highest In the United States the incidence of prostate cancer is 70 percent higher in African Americans than in white Americans and the death rate in African Americans is almost double that of white Americans The reasons for this excessive risk are unknown but both genetic and lifestyle factors have been suggested
Because Africans and African Americans share similar genetic ancestry but have vastly different lifestyles a better understanding of the rates and risk factor profiles for prostate cancer among Africans will provide important clues to what causes the disease This study will try to assess the incidence of prostate cancer in the West African nation of Ghana The study has two components
Clinical survey The methods of diagnosis at Korle-Bu will be evaluated and the incidence of prostate cancer over a 5-year period will be estimated
Screening and detection survey A survey of 1000 men between 50 and 74 years of age will estimate the prevalence of both asymptomatic and undiagnosed symptomatic prostate cancer in the Accra population
The clinical survey will use data from the cancer logbook and medical records at Korle-Bu Hospital and the Ghanaian National Census to derive an estimate of prostate cancer incidence within Accra The estimate will be low since it will be based only on men diagnosed or treated at Korle-Bu and will not include men with asymptomatic disease men diagnosed elsewhere or men without access to medical care The screening and detection survey will assess the presence of asymptomatic and unrecognized symptomatic prostate cancer using PSA testing and digital rectal examination in a random sample of 1000 men in the general population of Accra This will provide a high estimate of disease prevalence The two estimates will provide an approximation of the true incidence rate of the disease in Accra
Comparison of these data with similar data from community surveys of African Americans will provide insight into reasons for the excess risk of prostate cancer in African Americans
Because Africans and African Americans share similar genetic ancestry but have vastly different lifestyles a better understanding of the rates and risk factor profiles for prostate cancer among Africans will provide important clues to what causes the disease This study will try to assess the incidence of prostate cancer in the West African nation of Ghana The study has two components
Clinical survey The methods of diagnosis at Korle-Bu will be evaluated and the incidence of prostate cancer over a 5-year period will be estimated
Screening and detection survey A survey of 1000 men between 50 and 74 years of age will estimate the prevalence of both asymptomatic and undiagnosed symptomatic prostate cancer in the Accra population
The clinical survey will use data from the cancer logbook and medical records at Korle-Bu Hospital and the Ghanaian National Census to derive an estimate of prostate cancer incidence within Accra The estimate will be low since it will be based only on men diagnosed or treated at Korle-Bu and will not include men with asymptomatic disease men diagnosed elsewhere or men without access to medical care The screening and detection survey will assess the presence of asymptomatic and unrecognized symptomatic prostate cancer using PSA testing and digital rectal examination in a random sample of 1000 men in the general population of Accra This will provide a high estimate of disease prevalence The two estimates will provide an approximation of the true incidence rate of the disease in Accra
Comparison of these data with similar data from community surveys of African Americans will provide insight into reasons for the excess risk of prostate cancer in African Americans
Detailed Description:
OBJECTIVE The key aim of this study is to assess the burden of prostate cancer in Ghana and to evaluate how the impact of prostate cancer among West Africans compares with that among African Americans whose reported incidence rates are among the highest in the world West Africans and African Americans share genetic ancestry but have very different lifestyles and environmental exposures The study aim will be achieved by establishing lower and upper bounds on the true incidence of prostate cancer in the capital city of Accra The secondary aim of the study is to establish epidemiological biochemical and genetic profiles of West Africans for comparisons with African Americans to provide etiologic clues for prostate cancer DESIGN The study will consist of two components 1 a clinical survey a divided into a five-year retrospective and b a 3-year prospective phase and 2 a population screening survey
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-C-N240 | None | None | None |