Ignite Creation Date:
2024-05-06 @ 12:40 PM
Last Modification Date:
2024-10-26 @ 1:02 PM
Study NCT ID:
NCT03819517
Status:
COMPLETED
Last Update Posted:
2024-04-29
First Post:
2018-12-12
Brief Title:
Improving Cardiovascular Health in Patients With Chronic Obstructive Pulmonary Disease
Sponsor:
Virginia Commonwealth University
Organization:
Virginia Commonwealth University
Study Overview
Official Title:
Improving Cardiovascular Health in Patients With Chronic Obstructive Pulmonary Disease a Mechanistic Approach
Status:
COMPLETED
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Researchers have found a link between chronic obstructive pulmonary disease COPD and heart disease however a link is all they have found Cardiovascular health in COPD is controlled by different mechanisms including vascular health and systemic inflammation The investigators have collected preliminary data to support that concentrations of Sirtuin 1 Sirt1 a protein that plays a key role in cardioprotection may be involved in cardiovascular health in patients with COPD Resveratrol an over the counter natural polyphenol found in a variety of food is a direct activator of Sirt1 and has been used to improve cardiovascular health in different cohorts The current project is an attempt to expand previous findings and explore the effects of the sub-chronic use of resveratrol in sustaining the improvements in cardiovascular health in COPD
Detailed Description:
The present study is designed as a double-blind randomized cross-over placebo-controlled protocol Patients with COPD will receive either resveratrol 500 mg or placebo for 12 weeks A comprehensive evaluation of cardiovascular health will be performed Results will provide novel insights into the mechanistic role that Sirt1 mediates in COPD related vascular dysfunction and systemic inflammation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None