Ignite Creation Date:
2024-05-05 @ 4:53 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00332397
Status:
COMPLETED
Last Update Posted:
2008-06-17
First Post:
2006-05-31
Brief Title:
The Efficacy of Three Different Limus Agent-Eluting Stents to Prevent Restenosis
Sponsor:
Deutsches Herzzentrum Muenchen
Organization:
Deutsches Herzzentrum Muenchen
Study Overview
Official Title:
Randomized Comparison of 3 Limus Agent-Eluting Stents for the Reduction of Coronary Restenosis
Status:
COMPLETED
Status Verified Date:
2008-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ISAR-TEST-2
Brief Summary:
The purpose of this study is to evaluate the efficacy of 3 different drug-eluting-stent platforms to reduce coronary artery reblockage after stent implantation
Detailed Description:
Coronary artery reblockage remains still a drawback of percutaneous coronary interventions even in the era of drug-eluting stents DES DESs working principle consists of the delivery of controlled amounts of antiproliferative agents at the local level which results in the suppression of neontimal proliferation the main cause of lumen re-narrowing after stent implantationAt present several DES platforms have been developed and evaluated for clinical use They differ between them with regard to the stent type anti-proliferative drug presence of polymers employed for drug storage and modification of drug-release kinetics as well as type of polymer used for this purpose Most of the DES platforms have used agents from the limus family Although the majority of DESs employ polymer coating to control drug storage and release in view of the increasing safety and efficacy associated with the long-term presence of polymers a strong interest has recently been shown in the development DES platforms that do not require permanent polymers Trials as ACTION or JUPITER II have demonstrated that not all DESs are associated with the expected improved outcomes On the other hand not all successful DESs have been equally effective in the reduction of restenosis Thus rapamycin-eluting stents Cypher stents have been associated with lower angiographic and clinical restenosis rates than paclitaxel-eluting stents Taxus stents Similarly Cypher stents have been superior to Endeavor stents regarding the primary end point of late luminal loss in the recent ENDEAVOR III trial Meanwhile the on-site rapamycin-coated stents ISAR stents had an equivalent antiproliferative efficacy to Taxus stents in the ISAR-TEST trial However none of these studies evaluated angiographic restenosis as their primary endpoint and no direct comparisons between the 3 DES -Cypher Endeavor and ISAR stents have been performed The Cypher stent is a stainless steel stent coated with sirolimus with use of permanent polymers while the Endeavor stent is a cobalt alloy based stent coated with zotarolimus which also uses permanent polymers for drug-storage and release The ISAR stent is a rough surface stainless steel stent that can be coated with sirolimus in the cath lab without requiring permanent polymeric coating
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None