Ignite Creation Date:
2024-05-05 @ 11:08 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005266
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-05-25
Brief Title:
Cardiovascular Disease Mortality in The NAS-NRC Twin Registry
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To analyze cardiovascular disease mortality and total mortality in the NAS-NRC Twin Registry using a new methodology that allowed for censored observations of outcomes environmental covariates and unmeasured genotype-environment interactions
Detailed Description:
BACKGROUND
Methodologically statistical methods in genetics and epidemiology have developed largely independently and as a result there seemed to be little communication between the two fields Some of the most important hypotheses regarding familial aggregation of chronic diseases related to gene-environment interactions which drew on both fields The method of analysis used in this study dealt simultaneously with survival time nature of the outcome variable multiple and continuous environmental risk factors and correlation in outcomes between related individuals
The study was supported by the Small Grants Program established by the National Heart Lung and Blood Institute in January 1990 to extend analyses of research data generated by clinical trials population research and demonstration and education studies
DESIGN NARRATIVE
Data available from two epidemiologic questionnaires administered ten years apart were used to determine the extent to which an increased familial risk in cardiovascular disease mortality among twins was mediated by similarities in behavioral risk factors such as smoking diet weight changes physical activity and socioeconomic variables The contributions of genetic and environmental factors to twin similarities in health behavior were also examined
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Methodologically statistical methods in genetics and epidemiology have developed largely independently and as a result there seemed to be little communication between the two fields Some of the most important hypotheses regarding familial aggregation of chronic diseases related to gene-environment interactions which drew on both fields The method of analysis used in this study dealt simultaneously with survival time nature of the outcome variable multiple and continuous environmental risk factors and correlation in outcomes between related individuals
The study was supported by the Small Grants Program established by the National Heart Lung and Blood Institute in January 1990 to extend analyses of research data generated by clinical trials population research and demonstration and education studies
DESIGN NARRATIVE
Data available from two epidemiologic questionnaires administered ten years apart were used to determine the extent to which an increased familial risk in cardiovascular disease mortality among twins was mediated by similarities in behavioral risk factors such as smoking diet weight changes physical activity and socioeconomic variables The contributions of genetic and environmental factors to twin similarities in health behavior were also examined
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R03HL046115 | NIH | None | httpsreporternihgovquickSearchR03HL046115 |