Ignite Creation Date:
2024-05-06 @ 12:38 PM
Last Modification Date:
2024-10-26 @ 1:02 PM
Study NCT ID:
NCT03819712
Status:
COMPLETED
Last Update Posted:
2023-12-12
First Post:
2019-01-25
Brief Title:
Identification of Predictive Blood Biomarkers of Recurrent Urinary Tract Infections
Sponsor:
Centre Hospitalier Universitaire de Nice
Organization:
Centre Hospitalier Universitaire de Nice
Study Overview
Official Title:
Identification of Predictive Blood Biomarkers of Recurrent Urinary Tract Infections
Status:
COMPLETED
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Predict-UTI
Brief Summary:
Urinary tract infections affect more than 130 million people worldwide each year Almost 50 of women will have at least one urinary tract infection during their lifetime usually cystitis Half of them will have recurrent cystitis Antibiotics are the first-line treatment for cystitis but their effectiveness is decreasing due to the rapid spread of multi-resistant uro-pathogenic bacteria The objective of this study is to identify blood biomarkers associated with a high risk of recurrent cystitis Immune system cells and more specifically innate immunity cells play a key role in controlling urinary tract infections In addition clinical studies have shown that there is a high inter-individual variability in the ability of innate immune cells to respond to different stimuli We therefore hypothesized that there was an association between the risk of recurrent cystitis and a deficiency of certain immune cell types in producing certain pro-inflammatory cytokines including TNF-α in response to one or more bacterial stimuli particularly flagellin
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None