Ignite Creation Date:
2024-05-05 @ 4:52 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00339885
Status:
COMPLETED
Last Update Posted:
2020-05-27
First Post:
2006-06-19
Brief Title:
Mapping Genes for Type 2 Non-Insulin Dependent Diabetes Mellitus
Sponsor:
National Human Genome Research Institute NHGRI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Mapping Genes for Type 2 Non-Insulin Dependent Diabetes Mellitus
Status:
COMPLETED
Status Verified Date:
2020-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of the project is to positionally clone susceptibility genes for NIDDM Patients will be ascertained in Finland from previous health surveys and hospital discharge records Approximately 400 affected sib pairs will be collected Families will be chosen who have at most one parent with NIDDM no history of IDDM A clinical examination will be undertaken on family members and blood drawn for DNA isolation Covariates such as body weight blood pressure lipid levels and urinary albumin will also be measured The unaffected spouse and children of a subset of probands will be invited to undergo a frequently-sampled intravenous glucose tolerance test FSIGT to measure parameters of pancreatic function and peripheral insulin resistance IR A number of unrelated elderly non-diabetic subjects will also be identified to conduct a population-based association analysis
The FSIGT analysis will be performed in Los Angeles The DNA will be shipped to Bethesda where a total genomic scan will be performed using semi-automated fluorescence-based genotyping technology Data from Bethesda Los Angeles and Finland will be sent to Ann Arbor where parametric and non-parametric methods will be used to analyse both discrete traits such as NIDDM and intermediate traits like IR
The FSIGT analysis will be performed in Los Angeles The DNA will be shipped to Bethesda where a total genomic scan will be performed using semi-automated fluorescence-based genotyping technology Data from Bethesda Los Angeles and Finland will be sent to Ann Arbor where parametric and non-parametric methods will be used to analyse both discrete traits such as NIDDM and intermediate traits like IR
Detailed Description:
The Finland-United States investigation of NIDDM FUSION study is a long-term effort to
identify susceptibility genes for Type 2 diabetes T2D and associated quantitative traits This
involves the phenotyping and DNA analysis of thousands of individuals living in Finland utilizing a study design that was originally based on affected sib pairs The majority of these samples have already been subjected to a genome scan using microsatellite markers and the original FUSION samples Additionally thousands of other northern European cases and controls have been subjected to genome-wide association GWA analysis andor fine mapping as part of the FUSION study More recently the opportunity provided by the lowered sequencing costs have allowed targeted andor whole genome sequencing of many of these individuals
identify susceptibility genes for Type 2 diabetes T2D and associated quantitative traits This
involves the phenotyping and DNA analysis of thousands of individuals living in Finland utilizing a study design that was originally based on affected sib pairs The majority of these samples have already been subjected to a genome scan using microsatellite markers and the original FUSION samples Additionally thousands of other northern European cases and controls have been subjected to genome-wide association GWA analysis andor fine mapping as part of the FUSION study More recently the opportunity provided by the lowered sequencing costs have allowed targeted andor whole genome sequencing of many of these individuals
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| OH95-HG-N030 | None | None | None |