Ignite Creation Date:
2024-05-05 @ 4:52 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00332267
Status:
COMPLETED
Last Update Posted:
2008-09-04
First Post:
2006-05-31
Brief Title:
Cerebral Blood Flow and Metabolism During Hypoxia and Endotoxemia
Sponsor:
Rigshospitalet Denmark
Organization:
Rigshospitalet Denmark
Study Overview
Official Title:
Cerebral Blood Flow and Metabolism During Hypoxia and Endotoxemia
Status:
COMPLETED
Status Verified Date:
2008-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of the present protocol is to study whether a low level of oxygen in the blood will affect the immune response to as well as cerebral blood flow and metabolism during an infection and conversely whether the acute systemic and cerebral physiologic response to hypoxia is modified by an ongoing inflammatory response
Detailed Description:
The combination of acute infection and a low level of oxygen in the blood is a common phenomenon Thus acute hypoxia may complicate severe infections including severe sepsis Conversely healthy persons who ascend to moderately high altitudes which will be associated with a lowering of the inspired oxygen level may sustain an infection Even so it is unknown whether hypoxia modifies the systemic inflammatory response or conversely whether the reaction to hypoxia is influenced by the presence of systemic inflammation The present protocol aims to measure global cerebral blood flow metabolism and net flux as well as the systemic response in healthy volunteers who are subjected to either normobaric hypoxia alone N12 low-dose IV endotoxin infusion alone N12 or a combination of endotoxin infusion and normobaric hypoxia N12
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None