Ignite Creation Date:
2024-05-06 @ 12:37 PM
Last Modification Date:
2024-10-26 @ 1:01 PM
Study NCT ID:
NCT03805620
Status:
COMPLETED
Last Update Posted:
2024-05-29
First Post:
2019-01-07
Brief Title:
Effects of Combined Physical-cognitive Training on Cognitive Function in MCI
Sponsor:
Chiang Mai University
Organization:
Chiang Mai University
Study Overview
Official Title:
Synergistic Effects of Combined Physical-cognitive Training on Cognitive Function in Individuals With Mild Cognitive Impairment MCI A Randomized Controlled Trial
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The present study aims to investigate the effects of combined physical-cognitive training on cognitive function as well as peripheral BDNF level and mitochondrial function of individuals with MCI It is hypothesized that 1 the combined physical-cognitive training program will be superior to the physical and cognitive training program alone and 2 the degree of cognitive improvement will be positively correlated with the improvement of plasma BDNF and mitochondrial function
Detailed Description:
Recent research suggests that the benefits of combined physical-cognitive training may be greater than either physical or cognitive training alone Nevertheless this synergistic effect has been demonstrated mainly in cognitively intact older adults Studies examining the effects of combined physical-cognitive training in older adults with MCI are scarce and show mixed results Moreover few studies have determined the effects of the combined training on peripheral brain-derived neurotrophic factor BDNF and mitochondrial function Thus the present study aims to investigate the effects of combined physical-cognitive training on cognitive function as well as peripheral BDNF level and mitochondrial function of individuals with MCI The present study will provide insight into the interplay among the training program peripheral BDNF concentration mitochondrial function and cognitive function Importantly the findings will have clinical implication regarding the training program that is feasible and effective in improving cognitive function of older adults with MCI which ultimately will have great impact on public health as this population is at high risk of progression to AD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None