Ignite Creation Date:
2024-05-05 @ 4:52 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00330954
Status:
COMPLETED
Last Update Posted:
2010-03-05
First Post:
2006-05-26
Brief Title:
Gene Expression Profiling in Type 1 Diabetes
Sponsor:
Childrens Mercy Hospital Kansas City
Organization:
Childrens Mercy Hospital Kansas City
Study Overview
Official Title:
Gene Expression Profiling in Type 1 Diabetes
Status:
COMPLETED
Status Verified Date:
2010-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
One of the goals of the Kansas City Diabetes Consortium is to identify and characterize genes and their products that are associated with T1DM Characterization of such genes and their products can aid in developing new tools for risk assessment development of new prevention strategies and monitoring progression of disease
Study design Descriptive basic science pilot study The results of this pilot study will be used to help design a much larger study to address the importance of viral response and autoimmune diabetes
Study design Descriptive basic science pilot study The results of this pilot study will be used to help design a much larger study to address the importance of viral response and autoimmune diabetes
Detailed Description:
The hypothesis is that viral responsive genes are up-regulated prior to the onset of symptoms of Type 1 Diabetes T1DM and may correlate with increased expression of interferon alpha
Both genetic and environmental factors contribute to risk of development of T1DM There are a number of conflicting reports associating viral infections and T1DM in genetically susceptible individuals and causality has not been proven Viruses may not have a large role in the initiation of islet cell autoimmunity but more of a role in acceleration of the disease leading to overt symptoms There are no studies describing viral responsive gene expression in these individuals
Both genetic and environmental factors contribute to risk of development of T1DM There are a number of conflicting reports associating viral infections and T1DM in genetically susceptible individuals and causality has not been proven Viruses may not have a large role in the initiation of islet cell autoimmunity but more of a role in acceleration of the disease leading to overt symptoms There are no studies describing viral responsive gene expression in these individuals
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None