Ignite Creation Date:
2024-05-05 @ 4:52 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00337012
Status:
UNKNOWN
Last Update Posted:
2008-12-01
First Post:
2006-06-13
Brief Title:
The Effect of Duloxetine on Interoceptive Awareness
Sponsor:
University Hospital Bonn
Organization:
University Hospital Bonn
Study Overview
Official Title:
The Effect of Duloxetine on Interoceptive Awareness Thermal Heat Pain Perception and Bodily Symptoms in Major Depressive a Pilot Study With fMRI
Status:
UNKNOWN
Status Verified Date:
2008-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study focuses on possible mechanism mediating duloxetine effects on painful physical symptoms in patients suffering from MDD Our hypothesis is based on the assumption of dual impairment of the somatosensory system in these patients Hypalgesia to phasic experimental pain may be due to diminished spinal and brainstem transmission Hyperalgesia may be attributed to increased interoceptive perception somatic complaints especially those consisting in pain due to sensitisation or lack of inhibition of the interceptive perception These effects seem to be mediated by specific brain regions eg the right insula The investigators intent to test if duloxetine effects on these somatic complaints especially pain complaints are due to a normalization of these interceptive alterations which have been reported to be associated with depressive symptoms The investigators hypothesize that treatment with duloxetine will normalize pathological activation patterns as assessed by fMRI associated with increased interoceptive perception
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None