Ignite Creation Date:
2024-05-05 @ 4:52 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00334971
Status:
UNKNOWN
Last Update Posted:
2013-11-06
First Post:
2006-06-07
Brief Title:
Aromatase Activity and Ovarian Growth Factors in African-American Versus Caucasian Women
Sponsor:
Massachusetts General Hospital
Organization:
Massachusetts General Hospital
Study Overview
Official Title:
Aromatase Activity and Ovarian Growth Factors in Preovulatory Follicles
Status:
UNKNOWN
Status Verified Date:
2013-11
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the study is to understand how the ovarian follicle the fluid filled structure in the ovary that contains the egg makes estrogen and other hormones during normal aging in women with different ethnic backgrounds and in Fragile X premutation carriers
During reproductive aging estradiol levels are increased a phenomenon that may be related to increased aromatase activity The investigators own preliminary data suggest that estradiol is increased in African-American women compared to Caucasian women which may also be related to aromatase activity In addition the investigators have examined female fragile X premutation carriers who still have regular menstrual cycles and have demonstrated evidence of early ovarian aging compared to age-matched controls
WE ARE RECRUITING ONLY WOMEN WITH FRAGILE-X PREMUTATION
During reproductive aging estradiol levels are increased a phenomenon that may be related to increased aromatase activity The investigators own preliminary data suggest that estradiol is increased in African-American women compared to Caucasian women which may also be related to aromatase activity In addition the investigators have examined female fragile X premutation carriers who still have regular menstrual cycles and have demonstrated evidence of early ovarian aging compared to age-matched controls
WE ARE RECRUITING ONLY WOMEN WITH FRAGILE-X PREMUTATION
Detailed Description:
The purpose of the study is to examine intrafollicular changes in aromatase and ovarian growth factors in reproductive aged womenAfrican-American women compared to Caucasian controls and Fragile X premutation carriers
Hypotheses
Aromatase activity is up-regulated in preovulatory follicles with aging accounting for the increased estradiol levels in the face of decreased inhibin secretion in reproductive aging
Increased estradiol in the face of normal inhibin A and inhibin B suggests up-regulation of aromatase in African-American women
Aromatase activity is down-regulated in preovulatory follicles in fragile X premutation carriers compared to age-matched controls and the activity is associated with FMR1 mRNA levels
Hypotheses
Aromatase activity is up-regulated in preovulatory follicles with aging accounting for the increased estradiol levels in the face of decreased inhibin secretion in reproductive aging
Increased estradiol in the face of normal inhibin A and inhibin B suggests up-regulation of aromatase in African-American women
Aromatase activity is down-regulated in preovulatory follicles in fragile X premutation carriers compared to age-matched controls and the activity is associated with FMR1 mRNA levels
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| Sundry | OTHER | MGH-REU | None |