Ignite Creation Date:
2024-05-05 @ 11:08 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006276
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2000-09-14
Brief Title:
Micellar Paclitaxel to Treat Severe Psoriasis
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
A Pilot Open-Label Single-Dose Study Using Intravenous Micellar Paclitaxel for Patients With Severe Psoriasis
Status:
COMPLETED
Status Verified Date:
2002-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will evaluate the safety and effectiveness of micellar paclitaxel for treating severe psoriasis Paclitaxel in another formulation Taxol is approved by the Food and Drug Administration for use in patients with cancer This drug can decrease growth of cancer cells and of new blood vessels Because patients with psoriasis have an increase in skin cell and blood vessel growth paclitaxel may also improve their condition The dose of drug used in this study is much lower than those used to treat cancer patients and is expected to cause relatively few side effects
Patients 18 to 70 years of age with psoriasis lesions affecting at least 20 of their skin may be eligible for this study Candidates will be screened with a history and physical examination blood and urine tests electrocardiogram and possibly an exercise stress test
Participants will receive six intravenous through a vein infusions of paclitaxel over a 6-month period Each infusion will take about 2 hours Patients will stay in the clinic for observation for at least 1 hour before going home and will return to the clinic for follow-up examination and tests one week after each infusion However on weeks 0 and 8 visit will last for approximately 8 hours and will require a return to the clinic the following morning Blood collection will be performed during the week 0 and 8 visits to determine how fast Micellar Paclitaxel is eliminated from your body Approximately 2 teaspoons of blood will be taken prior to the infusion twice during the infusion and eight times during the 22 hours following the infusion for a total of eleven samples These return visits will last approximately 1-2 hours Patients will have the following procedures
1 A skin biopsy removal of a small tissue sample for microscopic examination will be done at the first visit week 0 and again at weeks 6 14 and 22 The area of the biopsy will be numbed with an anesthetic and a small circle of skin about the width of a pencil eraser and half as deep will be cut and lifted away Stitches will be placed and removed 1 to 2 weeks later
2 A history and physical examination will be done at every visit Patients will be interviewed about changes in their skin condition and about treatment side effects and will be examined by a nurse or physician
3 Blood and urine samples will be collected at frequent intervals nearly every visit to test for side effects
4 Photographs of the skin will be taken at the first visit and at several later visits to document changes in psoriasis
5 A blood sample will be drawn for genetic testing to look for gene changes in people with psoriasis
6 An electrocardiogram will be taken at the last visit This will be done at week 24 and compared to the screening EKG
7 Gonadal toxicity monitoring will be started with all patients entered into the protocol as of May 2001 Blood will be drawn to measure Inhibit A for females and Inhibit B for males at weeks 0 6 14 and 22
Patients 18 to 70 years of age with psoriasis lesions affecting at least 20 of their skin may be eligible for this study Candidates will be screened with a history and physical examination blood and urine tests electrocardiogram and possibly an exercise stress test
Participants will receive six intravenous through a vein infusions of paclitaxel over a 6-month period Each infusion will take about 2 hours Patients will stay in the clinic for observation for at least 1 hour before going home and will return to the clinic for follow-up examination and tests one week after each infusion However on weeks 0 and 8 visit will last for approximately 8 hours and will require a return to the clinic the following morning Blood collection will be performed during the week 0 and 8 visits to determine how fast Micellar Paclitaxel is eliminated from your body Approximately 2 teaspoons of blood will be taken prior to the infusion twice during the infusion and eight times during the 22 hours following the infusion for a total of eleven samples These return visits will last approximately 1-2 hours Patients will have the following procedures
1 A skin biopsy removal of a small tissue sample for microscopic examination will be done at the first visit week 0 and again at weeks 6 14 and 22 The area of the biopsy will be numbed with an anesthetic and a small circle of skin about the width of a pencil eraser and half as deep will be cut and lifted away Stitches will be placed and removed 1 to 2 weeks later
2 A history and physical examination will be done at every visit Patients will be interviewed about changes in their skin condition and about treatment side effects and will be examined by a nurse or physician
3 Blood and urine samples will be collected at frequent intervals nearly every visit to test for side effects
4 Photographs of the skin will be taken at the first visit and at several later visits to document changes in psoriasis
5 A blood sample will be drawn for genetic testing to look for gene changes in people with psoriasis
6 An electrocardiogram will be taken at the last visit This will be done at week 24 and compared to the screening EKG
7 Gonadal toxicity monitoring will be started with all patients entered into the protocol as of May 2001 Blood will be drawn to measure Inhibit A for females and Inhibit B for males at weeks 0 6 14 and 22
Detailed Description:
Paclitaxel is an antiangiogenic chemotherapeutic drug approved by the FDA for use in cancer There is anecdotal evidence that some patients with cancer and concomitant psoriasis have shown improvement in their skin while receiving paclitaxel for cancer Angiotech Pharmaceutical Inc the company with commercial rights over non-cancer uses of paclitaxel has data that suggests paclitaxel demonstrates anti-inflammatory and immunomodulatory properties in addition to the better known antiangiogenic and antiproliferative effects attributed to this compound In this pilot open-label single-dose study we initially treated patients with severe refractory psoriasis using intravenous Micellar Paclitaxel 75 mgm2 every 4 weeks for six months Because this dosing regimen was well tolerated and because the dosing interval seemed too long we now propose to treat patients with intravenous Micellar Paclitaxel at the adjusted dose of 375 mgm2 every 2 weeks
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 00-C-0211 | None | None | None |