Ignite Creation Date:
2024-05-05 @ 4:52 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00338676
Status:
UNKNOWN
Last Update Posted:
2017-03-01
First Post:
2006-06-19
Brief Title:
Aortic Stenosis in Elderly Determinant of Progression
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Aortic Stenosis in Elderly Determinant of Progression COFRASA French Cohort
Status:
UNKNOWN
Status Verified Date:
2016-02
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aortic stenosis AS is AS is caused by calcium deposits in the aortic valve Calcification is progressive and eventually leads to reduced leaflet motion with obstruction of the left ventricular outflow The only treatment is surgery There are evidences that AS is a regulated process with similarities to atherosclerosis but determinants of AS progression are unknown The study aims at evaluating these determinants and more specifically the role of lipids inflammation and platelet aggregation
Detailed Description:
Aortic stenosis AS is the most common valvular disease and the second most common indication for cardiac surgery in Western countries AS prevalence increases with age and with aging of the population AS is a major public health problem AS is due to calcium deposits within the aortic valve Calcium deposit is progressive and eventually leads to reduced leaflet motion with obstruction of the left ventricular outflow There is currently no effective medical therapy Once the stenosis is severe and patients symptomatic outcome is poor unless surgery aortic valve replacement is promptly performed AS has long been considered as a passive and degenerative process Recent data challenged this concept showing that AS is an active and highly regulated process with some similarities to atherosclerosis However AS progression is highly variable from one individual to another and determinants of AS progression are poorly known Their identification is crucial if we want to develop new medical strategies The aims of the present study are to identify the determinants of AS progression and more specifically to evaluate the role of lipids inflammation and platelet aggregation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None