Ignite Creation Date:
2024-05-06 @ 12:31 PM
Last Modification Date:
2024-10-26 @ 1:00 PM
Study NCT ID:
NCT03785171
Status:
UNKNOWN
Last Update Posted:
2018-12-24
First Post:
2018-12-20
Brief Title:
Predicative Value of Multimodal MRI in Moyamoya Disease
Sponsor:
Chinese PLA General Hospital
Organization:
Chinese PLA General Hospital
Study Overview
Official Title:
Multimodal Magnetic Resonance Imaging Predicting Outcome After Surgical Revascularization in Patients With Moyamoya Disease
Status:
UNKNOWN
Status Verified Date:
2018-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Moyamoya disease MMD is a nonatherosclerotic cerebrovascular abnormality characterized by a progressive stenosis or occlusion of the intracranial internal carotid arteries ICAs and their proximal branches with subsequent formation of collateral vessels puff of smoke In some cases the posterior circulation can also be involved MMD has been discovered around the world but Asians carry the most possibility to develop this disease Current treatment designed to prevent strokes by improving blood flow to the affected cerebral hemisphere including medical therapy and surgery In particular surgery included two general methods direct and indirect revascularization Compared with direct bypass indirect procedures are more technically accessible and may reduce the possibility of complications such as hyperperfusion In addition magnetic resonance imaging MRI with derived parameters have shown great potential in evaluating perfusion in patients and could possibly predict surgical outcome However there is still lack of evidence of the predictive value of MRI in evaluating clinical and angiography improvement in patients with MMD
Detailed Description:
Imaging protocols
3D TOF 3SLAB SWAN 3D ASL 20s T1 T2 T2 Flair DWI tASL 20s DCE APT-CEST
Imaging evaluation
1 Transfer contrast volume value measured by DCE
2 ASL shows CBF in associated regions
3 Stoke area measured by DWI and Flair
4 PH values reflected by APT-CEST
Treatment
Surgery-indirect revascularization
Follow-up
Baseline MRIDSA 3-months follow-up MRI 6-months follow-up MRIDSA
3D TOF 3SLAB SWAN 3D ASL 20s T1 T2 T2 Flair DWI tASL 20s DCE APT-CEST
Imaging evaluation
1 Transfer contrast volume value measured by DCE
2 ASL shows CBF in associated regions
3 Stoke area measured by DWI and Flair
4 PH values reflected by APT-CEST
Treatment
Surgery-indirect revascularization
Follow-up
Baseline MRIDSA 3-months follow-up MRI 6-months follow-up MRIDSA
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None