Ignite Creation Date:
2024-05-06 @ 12:31 PM
Last Modification Date:
2024-10-26 @ 1:00 PM
Study NCT ID:
NCT03789201
Status:
COMPLETED
Last Update Posted:
2022-10-26
First Post:
2018-12-27
Brief Title:
Exploring the Relationship Between Brain Asymmetry and Attention
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Exploring the Relationship Between Brain Asymmetry and Attention
Status:
COMPLETED
Status Verified Date:
2022-10-24
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background
People tend to pay more attention to one side of space than the other and this may be due to differences in the structure and function of the two sides of the brain We are interested in whether we can detect those difference with magnetic resonance imaging MRI transcranial magnetic stimulation TMS and electroencephalography EEG
Objective
The purpose of the study is to understand how differences in brain structure may cause people to pay more attention to one side than the other
Eligibility
Healthy adults ages 18-35
Design
Participants will be screened with a neurological exam
Participants will have 2-3 visits for a total duration of about 78 hours
Women of childbearing age must have a negative pregnancy test before each MRI scan
Visits may include
Physical exam
Tests of attention and thinking
TMS A brief electrical current will pass through a wire coil on the scalp Participants will hear a click and may feel a pull They may be asked to tense muscles or do tasks
Magnetic resonance imaging MRI scan for a maximum of 1 hour Participants will lie on a table that slides into a cylinder in a strong magnetic field They will do tasks on a computer screen or lie still They will get earplugs for loud noise
EEG for no longer than 5 hours with most lasting 3 hours Gel and a cap with electrodes will be placed on the scalp They will record brain waves while the participant gets TMS or does nothing
Questions about participants dominant hand and about the MRI
People tend to pay more attention to one side of space than the other and this may be due to differences in the structure and function of the two sides of the brain We are interested in whether we can detect those difference with magnetic resonance imaging MRI transcranial magnetic stimulation TMS and electroencephalography EEG
Objective
The purpose of the study is to understand how differences in brain structure may cause people to pay more attention to one side than the other
Eligibility
Healthy adults ages 18-35
Design
Participants will be screened with a neurological exam
Participants will have 2-3 visits for a total duration of about 78 hours
Women of childbearing age must have a negative pregnancy test before each MRI scan
Visits may include
Physical exam
Tests of attention and thinking
TMS A brief electrical current will pass through a wire coil on the scalp Participants will hear a click and may feel a pull They may be asked to tense muscles or do tasks
Magnetic resonance imaging MRI scan for a maximum of 1 hour Participants will lie on a table that slides into a cylinder in a strong magnetic field They will do tasks on a computer screen or lie still They will get earplugs for loud noise
EEG for no longer than 5 hours with most lasting 3 hours Gel and a cap with electrodes will be placed on the scalp They will record brain waves while the participant gets TMS or does nothing
Questions about participants dominant hand and about the MRI
Detailed Description:
Objective
The goal of this protocol to explore correlations between lateralized individual differences in visual attentional preference and hemispheric asymmetries in functional connectivity between the frontal and parietal visual attention areas To measure functional connectivity resting state functional MRI and electroencephalographic EEG potentials evoked with transcranial magnetic stimulation TMS will be used Protocol research will also attempt to validate the TMS-evoked EEG potentials against fMRI resting state functional connectivity
Study Population
Up to 80 right-handed and right-eyed healthy volunteers aged 18-35
Design
TMS evoked EEG potentials TEPs and fMRI will be used to measure functional connectivity between the posterior parietal cortex and the frontal visual attention area Various tasks will be used to quantify attention and explore their relationship with asymmetries in functional connectivity A qualitative comparison between the value of fMRI and TEPs for predicting attentional bias will be made
Outcome Measures
Behavioral measures of attention
TEP measures of functional connectivity
fMRI measures of functional connectivity
The goal of this protocol to explore correlations between lateralized individual differences in visual attentional preference and hemispheric asymmetries in functional connectivity between the frontal and parietal visual attention areas To measure functional connectivity resting state functional MRI and electroencephalographic EEG potentials evoked with transcranial magnetic stimulation TMS will be used Protocol research will also attempt to validate the TMS-evoked EEG potentials against fMRI resting state functional connectivity
Study Population
Up to 80 right-handed and right-eyed healthy volunteers aged 18-35
Design
TMS evoked EEG potentials TEPs and fMRI will be used to measure functional connectivity between the posterior parietal cortex and the frontal visual attention area Various tasks will be used to quantify attention and explore their relationship with asymmetries in functional connectivity A qualitative comparison between the value of fMRI and TEPs for predicting attentional bias will be made
Outcome Measures
Behavioral measures of attention
TEP measures of functional connectivity
fMRI measures of functional connectivity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 19-N-0036 | None | None | None |