Ignite Creation Date:
2024-05-06 @ 12:30 PM
Last Modification Date:
2024-10-26 @ 12:59 PM
Study NCT ID:
NCT03775941
Status:
COMPLETED
Last Update Posted:
2018-12-19
First Post:
2018-11-29
Brief Title:
Fitness on White Matter and Cognition in Aging
Sponsor:
Suffolk University
Organization:
Suffolk University
Study Overview
Official Title:
Neuroprotective Effects of Cardiorespiratory Fitness on White Matter Integrity and Cognition Across the Adult Lifespan
Status:
COMPLETED
Status Verified Date:
2018-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Cardiorespiratory fitness CRF is associated with decreased risk for mild cognitive impairment MCI and dementia CRF is linked with more conserved gray and white matter WM volume improved WM microstructural integrity and better cognitive performance among healthy older adults Additional research is needed to determine 1 which WM tracts are most strongly related to CRF 2 whether CRF-related benefits on WM translate to enhanced cognitive functioning and 3 factors that mediate and moderate CRF effects Higher CRF was hypothesized to be associated with stronger WM integrity both globally and locally in WM tracts that connect frontal brain regions The neuroprotective effects were hypothesized to be age-dependent such that the association between CRF and WM integrity would be stronger in old age compared to younger age Finally higher CRF was hypothesized to predict stronger performance on tests of executive functioning EF partially mediated by frontal WM integrity Delineation of specific neurocognitive effects of CRF may serve clinicians in individually tailoring wellness interventions to meet patients specific cognitive concerns with aging
Detailed Description:
Sample Participant data from the Cross-Sectional Lifespan Connectomics Study of the Nathan Kline Institute - Rockland Sample NKI-RS will be analyzed for the present study Zip code-based recruitment and monitoring enrollment for key demographic variables eg age sex ethnicity were used to maintain adequate representation of Rockland County and prevent sampling biases eg cohort effects NKI-RS eligibility was designed for inclusivity
Procedure All participants completed a medical evaluation psychiatric interview self-report questionnaires standardized battery of cognitive tests and neuroimaging at NKI Complete details about the MRI measurement parameters can be located on the NKI-RS website for DTI and MPRAGE and protocols Quality assurance of raw data inclusive of monitoring standard operating procedures error-handling and compiling the data dictionary is maintained by NKI-RS Raw neuroimaging data was acquired by NKI-RS and processed at Suffolk University using TRACULA and FreeSurfer 53
Statistical Plan Analyses will be performed on de-identified phenotypic and neuroimaging data from adult NKI-RS participants available at the start of this study October 2016 Analyses will evaluate the potential for CRF to modulate decline in WM integrity and EF observed with aging Mixed-effects modeling will investigate the extent to which CRF predicts WM integrity as both a global measurement of fractional anisotropy FA and FA within nine major WM tracts Structural equation modeling will examine whether higher FA within frontal WM tracts partially mediates a positive relationship between CRF and EF The role of age and clinical characteristics eg cardiovascular risk factors depression will also be explored as covariates in the link between CRF WM and EF
Procedure All participants completed a medical evaluation psychiatric interview self-report questionnaires standardized battery of cognitive tests and neuroimaging at NKI Complete details about the MRI measurement parameters can be located on the NKI-RS website for DTI and MPRAGE and protocols Quality assurance of raw data inclusive of monitoring standard operating procedures error-handling and compiling the data dictionary is maintained by NKI-RS Raw neuroimaging data was acquired by NKI-RS and processed at Suffolk University using TRACULA and FreeSurfer 53
Statistical Plan Analyses will be performed on de-identified phenotypic and neuroimaging data from adult NKI-RS participants available at the start of this study October 2016 Analyses will evaluate the potential for CRF to modulate decline in WM integrity and EF observed with aging Mixed-effects modeling will investigate the extent to which CRF predicts WM integrity as both a global measurement of fractional anisotropy FA and FA within nine major WM tracts Structural equation modeling will examine whether higher FA within frontal WM tracts partially mediates a positive relationship between CRF and EF The role of age and clinical characteristics eg cardiovascular risk factors depression will also be explored as covariates in the link between CRF WM and EF
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01MH094639-01 | NIH | None | httpsreporternihgovquickSearchR01MH094639-01 |