Ignite Creation Date:
2024-05-06 @ 12:30 PM
Last Modification Date:
2024-10-26 @ 1:00 PM
Study NCT ID:
NCT03778723
Status:
COMPLETED
Last Update Posted:
2020-09-04
First Post:
2018-12-16
Brief Title:
Effect of Propofol Midazolam on Cerebral Oxygenation and Metabolism During Clipping of Ruptured Cerebral Aneurysm
Sponsor:
Mansoura University
Organization:
Mansoura University
Study Overview
Official Title:
Cerebral Oxygenation and Metabolism in Patients Undergoing Clipping of Cerebral Aneurysm A Comparative Study Between Propofol-based Total Intravenous Anesthesia and Sevoflurane-based Inhalational Anesthesia
Status:
COMPLETED
Status Verified Date:
2020-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Despite the theoretical benefits of iv agents volatile agents remain popular In a study comparing desflurane isoflurane and sevoflurane in a porcine model of intracranial hypertension at equipotent doses and normocapnia cerebral blood flow CBF and ICP were least with sevoflurane
Propofol is the most commonly used intravenous anesthetic It has many theoretical advantages by reducing cerebral blood volume CBV and ICP and preserving both autoregulation and vascular reactivity Neurosurgical patients anaesthetized with propofol were found to have lower ICP and higher CPP than those anaesthetized with isoflurane or sevoflurane
The well known pharmacodynamic advantages of intravenous anesthetics may give this group of drugs superior cerebral effects when compared with inhalation anesthetics
Propofol is the most commonly used intravenous anesthetic It has many theoretical advantages by reducing cerebral blood volume CBV and ICP and preserving both autoregulation and vascular reactivity Neurosurgical patients anaesthetized with propofol were found to have lower ICP and higher CPP than those anaesthetized with isoflurane or sevoflurane
The well known pharmacodynamic advantages of intravenous anesthetics may give this group of drugs superior cerebral effects when compared with inhalation anesthetics
Detailed Description:
The aim of this study is to evaluate the cerebral hemodynamics and global cerebral oxygenation as well as the systemic hemodynamic changes using midazolam and propofol as total intravenous anesthetics TIVA in comparison with sevoflurane anesthesia in clipping of ruptured cerebral aneurysm
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None