Ignite Creation Date:
2024-05-05 @ 4:51 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00327236
Status:
COMPLETED
Last Update Posted:
2019-04-10
First Post:
2006-05-17
Brief Title:
The Study of Immune Cell T Cell Activity in Patients With Paraneoplastic Neurologic Syndromes
Sponsor:
Rockefeller University
Organization:
Rockefeller University
Study Overview
Official Title:
Killer T Cell Activity in the Paraneoplastic Neurologic Syndromes
Status:
COMPLETED
Status Verified Date:
2019-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators believe that T cells cells that are a part of the immune system are what are causing the neurological problems while also attacking tumor cells This protocol studies the clinical status of patients with paraneoplastic neurological disorder PND as well as their blood to understand the relationship between their neurological disease their cancer and their immune system
Detailed Description:
Patients with paraneoplastic neurological disorders PNDs provide a unique model for studying tumor immunity and neuronal autoimmunity We hypothesize that T lymphocyte autoimmune dysfunction is involved in the pathogenesis of the paraneoplastic neurological syndromes and that killer T cells are involved in the targeting and successful killing of tumor cells in these cancer patients Furthermore we postulate that this activity may provide a model for autoimmune brain disease We will assess the immune responses in PND patients correlate these with the clinical data time course of disease symptoms and signs disability and collect and archive clinical data serum and cells from PND patients for current and future studies into the basic immune system phenomenon present in PND patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None