Ignite Creation Date:
2024-05-05 @ 11:08 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001622
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Study of the Response of Human Small Blood Vessels
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Study of the Relation Between In Vivo and In Vitro Response of Human Small Vessels
Status:
COMPLETED
Status Verified Date:
2000-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A layer of cells called the endothelium line the walls of blood vessels These cells produce substances that control the tone of blood vessels and thus control blood flow through the vessel One of the substances produced involved in the control of blood vessel function is nitric oxide Nitric oxide NO plays a role in the relaxation of blood vessels
Researchers have been interested in the function of the endothelium in patients with high blood pressure essential hypertension and patients with high cholesterol hypercholesterolemia
After conducting studies on the endothelium and nitric oxide researchers have found that the endothelium is indeed functioning abnormally in patients with high blood pressure and high cholesterol In addition researchers have determined that the dysfunction is a result of abnormalities in the nitric oxide NO system
In this study researchers plan to investigate the relationship between blood vessel responses in real-life settings versus laboratory settings in normal volunteers patients with high blood pressure and patients with high cholesterol
Researchers have been interested in the function of the endothelium in patients with high blood pressure essential hypertension and patients with high cholesterol hypercholesterolemia
After conducting studies on the endothelium and nitric oxide researchers have found that the endothelium is indeed functioning abnormally in patients with high blood pressure and high cholesterol In addition researchers have determined that the dysfunction is a result of abnormalities in the nitric oxide NO system
In this study researchers plan to investigate the relationship between blood vessel responses in real-life settings versus laboratory settings in normal volunteers patients with high blood pressure and patients with high cholesterol
Detailed Description:
Over the last ten years we have been interested in the investigation of endothelial function in patients with essential hypertension and patients with hypercholesterolemia We have performed intra-arterial infusion of endothelium-dependent and endothelium-independent drugs into the brachial artery with noninvasive measurement of the response of the forearm vasculature by means of strain gauge plethysmography Those studies have allowed us to a demonstrate the presence of endothelial dysfunction in patients with essential hypertension and in patients with hypercholesterolemia and b identify an abnormality in the endothelium-derived nitric oxide system that is responsible for endothelial dysfunction in these patients Further studies to more precisely determine the intracellular processes that mediate this abnormality in endothelial function in these patients are limited by the inherent shortcomings of the in vivo technique An alternative possibility is the study of human small vessels in vitro however the relationship between in vivo and in vitro vascular responses to endothelium-dependent and -independent agonists has not been established In the present study we propose to investigate this relationship in normal volunteers patients with essential hypertension and patients with hypercholesterolemia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 97-H-0098 | None | None | None |