Ignite Creation Date:
2024-05-06 @ 12:29 PM
Last Modification Date:
2024-10-26 @ 12:59 PM
Study NCT ID:
NCT03772951
Status:
COMPLETED
Last Update Posted:
2022-01-11
First Post:
2018-10-24
Brief Title:
The Efficacy of Computerized Cognitive Remediation Therapy for Chronic Schizophrenia
Sponsor:
Shanghai Mental Health Center
Organization:
Shanghai Mental Health Center
Study Overview
Official Title:
The Efficacy for Execution Function and Genetic Mechanism of Computerized Cognitive Remediation Therapy for Chronic Schizophrenia
Status:
COMPLETED
Status Verified Date:
2021-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study group received antipsychotic drugs combined with Computerized Cognitive Remediation Therapy CCRT for 4 timesweek for 45 minutes each time The control group only received antipsychotic drugs For a total of 12 weeks Brain Derived Neurotrophic Factor BDNF and Tropomyosin-related kinase B Trk B genes in peripheral blood were detected in both groups before and after treatment Clinical symptoms and executive function assessment were performed in both groups before and after treatment The relevance of genes and their effects on downstream protein expression levels led to a molecular genetic mechanism for the efficacy of Computerized Cognitive Remediation Therapy CCRT
Detailed Description:
Among the cognitive disorders of chronic schizophrenia the most reported is the executive dysfunction of the prefrontal lobe There is increasing evidence that Computerized Cognitive Remediation Therapy CCRT has a significant improvement in the implementation of schizophrenia but the specific mechanism is unknown Therefore this study plans to select 154 patients with chronic schizophrenia who were hospitalized for a long time They were randomly divided into two groups The study group received antipsychotic drugs combined with Computerized Cognitive Remediation Therapy CCRT for 4 timesweek for 45 minutes each time The control group only received antipsychotic drugs For a total of 12 weeks brain-derived neurotrophic factor BDNF and tyrosine receptor kinase BTRK-B genes in peripheral blood were detected in both groups before and after treatment Clinical symptoms and executive function assessment were performed in both groups before and after treatment The relevance of genes and their effects on downstream protein expression levels led to a molecular genetic mechanism for the efficacy of Computerized Cognitive Remediation Therapy CCRT
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None