Ignite Creation Date:
2024-05-06 @ 12:28 PM
Last Modification Date:
2024-10-26 @ 12:59 PM
Study NCT ID:
NCT03767023
Status:
COMPLETED
Last Update Posted:
2018-12-14
First Post:
2018-10-26
Brief Title:
Clinical and Microbiological Relationships Between Periodontitis and Abdominal Aorta Aneurism an Case Control Study
Sponsor:
University of Liege
Organization:
University of Liege
Study Overview
Official Title:
Clinical and Microbiological Relationships Between Periodontitis and Abdominal Aorta Aneurism an Case Control Study
Status:
COMPLETED
Status Verified Date:
2018-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aorta Abdominal aneurism AAA is a chronic degenerative disorder leading to the dilation and eventually to the rupture of the aortic wall The pathology presents risk factors such as aging atherosclerosis male gender cigarette smoking pulmonary emphysema and high blood pressureThe vascular wall destruction is characterized by a remodeling of the extracellular matrix ECM the presence of an inflammatory infiltrate of macrophages and lymphocytes associated increase in production of MMPs A similar destruction mechanisms is found in periodontitis a chronic inflammatory diseases characterized by gram-negative bacteria species that are able to degrade ECM of the tooth supporting tissues and leading finally to tooth loss Moreover relationships between periodontitis and cardiovascular disease have already been demonstrated These associations are considered to be initiated by transient or prolonged bacteremia due to dissemination of oral bacteria or their products into the bloodstream The periopathogens more specifically Porphyromonas gingivalis Pg were observed in atherosclerosis and aneurysm specimens as well as in coronary heart disease and endocarditis The association between periodontitis and Abdominal Aortic Aneurysms AAA has not often been studied especially from a clinical aspect The mechanisms that induce the initiation the development or the recurrence and the rupture of AAA after a period of quiescence not well studied and are therefore still unknown
The aim of this clinical observational case controlled study is to search for a possible relationship between periodontal disease and rapid growth of AAA Patients presenting stable or unstable AAA will be screened for the degree of periodontitis for the type of oral microbiology and periodontopathogen markers present in the blood stream
The aim of this clinical observational case controlled study is to search for a possible relationship between periodontal disease and rapid growth of AAA Patients presenting stable or unstable AAA will be screened for the degree of periodontitis for the type of oral microbiology and periodontopathogen markers present in the blood stream
Detailed Description:
31 consecutive dentulous patients diagnosed for AAA requiring a cardiovascular surgery instable AAA and 31 consecutive dentulous patients with stable AAA no need for cardiovascular surgery will be recruited from the Cardiovascular Surgery Department of the University Hospital of Liège Faculty of Medicine University of Liège Belgium - Pr N Sakalihasan The 62 patients will be subjected to
1 Full clinical periodontal parameter assessment
2 Microbiological analyses of saliva
3 Supra- and sub- gingival microbiological test
4 Blood test for biomarker analysis
5 Imaging echography CT-Scansmeasurments
1 Full clinical periodontal parameter assessment
2 Microbiological analyses of saliva
3 Supra- and sub- gingival microbiological test
4 Blood test for biomarker analysis
5 Imaging echography CT-Scansmeasurments
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None