Ignite Creation Date:
2024-05-06 @ 12:26 PM
Last Modification Date:
2024-10-26 @ 12:59 PM
Study NCT ID:
NCT03763487
Status:
UNKNOWN
Last Update Posted:
2018-12-04
First Post:
2018-10-12
Brief Title:
The Aim of This Project is to Verify Whether a Depletion of B Cell Memory Subpopulation Marginal-zone-like CD19 IgD CD27 and CD19 IgM CD27 is a Useful Indicator of Hyposplenism in Patients With Celiac Disease
Sponsor:
University Hospital Hradec Kralove
Organization:
University Hospital Hradec Kralove
Study Overview
Official Title:
Marginal Zone Similar to B Lymphocytes in Peripheral Blood in Patients With Celiac Disease
Status:
UNKNOWN
Status Verified Date:
2018-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This project is expected to confirm the hypothesis that hyposplenism in patients with celiac disease is not conditioned by a selective memory deficiency of B lymphocytes
Other objectives of project are
determination of gliadin 33-mer in faecal and urine as indicators patients adherence to gluten-free diet
determination of citrulline in plasma as an indicator of the overall functional capacity enterocytes
Other objectives of project are
determination of gliadin 33-mer in faecal and urine as indicators patients adherence to gluten-free diet
determination of citrulline in plasma as an indicator of the overall functional capacity enterocytes
Detailed Description:
Ultrasound examination is focused to spleen size spleen volumetry Methodology of laboratory examinations is based on venous blood sampling for the determination of memory B-like marginal zone by flow cytometry gliadin 33-mer ELISA determination in faecal and urine sample blood plasma extraction for citrulline high performance liquid chromatography HPLC
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None