Ignite Creation Date:
2024-05-06 @ 12:25 PM
Last Modification Date:
2024-10-26 @ 12:58 PM
Study NCT ID:
NCT03756727
Status:
UNKNOWN
Last Update Posted:
2018-11-28
First Post:
2018-11-25
Brief Title:
Effect of Ascorbic Acid on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery
Sponsor:
Xuzhou Medical University
Organization:
Xuzhou Medical University
Study Overview
Official Title:
Effect of Perioperative Application of Ascorbic Acid on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery
Status:
UNKNOWN
Status Verified Date:
2018-11
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Postoperative pulmonary complicationsPPCs including but not limited to hypoxemia pneumonia ventilator-induced lung injury and acute respiratory distress syndrome ARDSatelectasispleural effusion PPCs may result in increased resources utilization delayed mobilization prolonged need of supplemental oxygen or mechanical ventilationand a longer hospital staypostoperative pulmonary complications are common after cardiac surgery often increasing postoperative morbidity and mortalityThe extracorporeal circulationincreased oxygen concentration inhaled and the development of massive atelectasis after open-chest surgery commonly activate lung inflammation amplifying the harm Injury of pulmonary Currently plenty of interventions have been studied to prevent PPCs after surgery Most of the recent research has focused on physical therapy such as lung-protective modes during intraoperative mechanical ventilation Alveolar Recruitment and respiratory muscle trainingThese therapies have a certain effect but still not satisfactoryAscorbic acid is an important cofactor in multiple enzymatic reactions where its main function is as a reducing agentStudies have shown that ascorbic acid can reduce both ischemia-reperfusion injury and oxidative stress Unfortunately no studies examined whether Ascorbic acid can reduce PPCs
Detailed Description:
The possible mechanisms of ascorbic acid to alleviate ischemia-reperfusion injury are as follows 1 Ascorbic acid as a first-line antioxidant in plasma can reduce stress by eliminating excess Reactive oxygen species and reduce damage 2 provides rapid electron transfer to react with superoxide and hydroxyl group to scavenge reactive oxygen released into the circulation 3 Ascorbic acid can reduce lipid peroxidation and reduce lung injury caused by ischemia-reperfusion by scavenging oxygen free radicals 4 Vitamin C can promote the production of cytokines by immune cells to reduce local inflammatory reactions and improve tissue microcirculationThe study aims to explore whether daily used Ascorbic acid in the perioperative period has a preventive effect on PPCs in patients undergoing cardiac surgery and through short-term and long-term follow-up to investigate the effect on post-hospitalization Prognosis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None