Ignite Creation Date:
2024-05-06 @ 12:23 PM
Last Modification Date:
2024-10-26 @ 12:58 PM
Study NCT ID:
NCT03747315
Status:
COMPLETED
Last Update Posted:
2021-06-08
First Post:
2018-11-14
Brief Title:
A Diagnostic Test for Familial Mediterranean Fever
Sponsor:
Hospices Civils de Lyon
Organization:
Hospices Civils de Lyon
Study Overview
Official Title:
Assessment of a Functional Test to Detect Familial Mediterranean Fever
Status:
COMPLETED
Status Verified Date:
2021-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DEPIST-FMF
Brief Summary:
Familial Mediterranean Fever FMF is the most common auto-inflammatory disease prevalence 1-5 10000 inhabitants It is due to mutations of the MEFV gene encoding variants of the Pyrin inflammasome Inflammasomes are protein complexes of innate immunity producing pro-inflammatory cytokines interleukin-1β
In vitro preliminary results demonstrated that activation of the Pyrin inflammasome measured by interleukin-1β concentration by kinase inhibitors is significantly increased in FMF patients compared to subjects with a similar clinical picture and healthy controls In addition a measure of cell death yielded significant results in differentiating patients from controls
The investigators hypothesize that this fast and simple functional test can serve as a diagnostic tool for FMF
In vitro preliminary results demonstrated that activation of the Pyrin inflammasome measured by interleukin-1β concentration by kinase inhibitors is significantly increased in FMF patients compared to subjects with a similar clinical picture and healthy controls In addition a measure of cell death yielded significant results in differentiating patients from controls
The investigators hypothesize that this fast and simple functional test can serve as a diagnostic tool for FMF
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None