Ignite Creation Date:
2024-05-06 @ 12:20 PM
Last Modification Date:
2024-10-26 @ 12:57 PM
Study NCT ID:
NCT03731156
Status:
COMPLETED
Last Update Posted:
2020-03-10
First Post:
2018-11-02
Brief Title:
Granulomatous Pneumocystis Pneumonia
Sponsor:
University Hospital Montpellier
Organization:
University Hospital Montpellier
Study Overview
Official Title:
Biological Diagnosis of Granulomatous Pneumocystis Pneumonia
Status:
COMPLETED
Status Verified Date:
2020-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NC
Brief Summary:
The intra-alveolar form of Pneumocystis jiroveci pneumonia PjP is a common pathology in immunocompromised patients particularly those infected with HIV The diagnosis is based on the detection of Pj in a LBA Intra-tissue granulomatous form PGP is a rare entity observed in non-HIV immunocompromised patients In this case the LBA is mostly non-contributory and the diagnosis is based solely on the detection of cysts on histological examination on biopsy of a pulmonary nodule For many years it has been clearly demonstrated that the use of a specific PCR clearly improves the biological diagnosis of PcP However in case of granulomatous form this method is not implemented because the diagnostic hypothesis is not mentioned
In 2018 two cases of PGP were diagnosed at 3-month intervals at Montpellier University Hospital Center The diagnostic confirmation was obtained with PCR Pj In this context the investigators will investigate the interest of implementing PCR Pj on biopsies on pulmonary nodules from hospitalized patients between 2015 and 2018 In all selected patients histopathological aspect of the nodule was compatible with a PGP and no other diagnosis has been confirmed infectious tumoral inflammatory Finally 17 patients were selected to check retrospectively if the presence of Pj could be at the origin of the pathology
In 2018 two cases of PGP were diagnosed at 3-month intervals at Montpellier University Hospital Center The diagnostic confirmation was obtained with PCR Pj In this context the investigators will investigate the interest of implementing PCR Pj on biopsies on pulmonary nodules from hospitalized patients between 2015 and 2018 In all selected patients histopathological aspect of the nodule was compatible with a PGP and no other diagnosis has been confirmed infectious tumoral inflammatory Finally 17 patients were selected to check retrospectively if the presence of Pj could be at the origin of the pathology
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None