Ignite Creation Date:
2024-05-06 @ 12:14 PM
Last Modification Date:
2024-10-26 @ 12:56 PM
Study NCT ID:
NCT03717168
Status:
COMPLETED
Last Update Posted:
2019-08-21
First Post:
2018-10-22
Brief Title:
Effects of Growth Hormone on Difficult Ventilator Weaning Patients
Sponsor:
National Cancer Institute Egypt
Organization:
National Cancer Institute Egypt
Study Overview
Official Title:
Role of Recombinant Human Growth Hormone rHGH in Weaning of Prolonged Ventilation After Major Abdominal Cancer Surgeries
Status:
COMPLETED
Status Verified Date:
2019-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Major abdominal surgeries may be followed by postoperative pulmonary complications PPCs These complications are common and can cause significant morbidity and mortality
Major operations are followed by acute respiratory insufficiency RI in 3-274 which causes prolonged hospital stay high patient costs high mortality rate and lower survival rates The most crucial pulmonary postoperative complication is the prolonged mechanical ventilation and difficult weaningThe rHGH is a synthetic metabolic hormone which improves synthesis of protein corrects hypoalbumenia reverses negative nitrogen balance improves patient nutrition improves wound healing and promotes recovery of respiratory muscle function When used for weaning from mechanical ventilation rHGH reducess the duration of mechanical ventilation time ICU admission period incidence of VAP ICU mortality
Major operations are followed by acute respiratory insufficiency RI in 3-274 which causes prolonged hospital stay high patient costs high mortality rate and lower survival rates The most crucial pulmonary postoperative complication is the prolonged mechanical ventilation and difficult weaningThe rHGH is a synthetic metabolic hormone which improves synthesis of protein corrects hypoalbumenia reverses negative nitrogen balance improves patient nutrition improves wound healing and promotes recovery of respiratory muscle function When used for weaning from mechanical ventilation rHGH reducess the duration of mechanical ventilation time ICU admission period incidence of VAP ICU mortality
Detailed Description:
Major abdominal surgeries may be followed by postoperative pulmonary complications PPCs These complications are common and can cause significant morbidity and mortality
Major operations are followed by acute respiratory insufficiency RI in 3-274 which causes prolonged hospital stay high patient costs high mortality rate and lower survival rates The most crucial pulmonary postoperative complication is the prolonged mechanical ventilation and difficult weaningThe rHGH is a synthetic metabolic hormone which improves synthesis of protein corrects hypoalbumenia reverses negative nitrogen balance improves patient nutrition improves wound healing and promotes recovery of respiratory muscle function When used for weaning from mechanical ventilation rHGH reducess the duration of mechanical ventilation time ICU admission period incidence of VAP ICU mortality Felbinger et al reported a case of prolonged ventilation with failure of weaning after 42 days the patient received subcutaneous rHGH 03 IUkgday for 20 days in addition to intensive care standard management They reported improvement of protein metabolism in addition to improvement of respiratory muscle strength the patient was weaned successfully on the 75th postoperative daythis study assumes a hypothesis that rHGH would help weaning from mechanically ventilated tracheostomized patients
Major operations are followed by acute respiratory insufficiency RI in 3-274 which causes prolonged hospital stay high patient costs high mortality rate and lower survival rates The most crucial pulmonary postoperative complication is the prolonged mechanical ventilation and difficult weaningThe rHGH is a synthetic metabolic hormone which improves synthesis of protein corrects hypoalbumenia reverses negative nitrogen balance improves patient nutrition improves wound healing and promotes recovery of respiratory muscle function When used for weaning from mechanical ventilation rHGH reducess the duration of mechanical ventilation time ICU admission period incidence of VAP ICU mortality Felbinger et al reported a case of prolonged ventilation with failure of weaning after 42 days the patient received subcutaneous rHGH 03 IUkgday for 20 days in addition to intensive care standard management They reported improvement of protein metabolism in addition to improvement of respiratory muscle strength the patient was weaned successfully on the 75th postoperative daythis study assumes a hypothesis that rHGH would help weaning from mechanically ventilated tracheostomized patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None