Ignite Creation Date:
2024-05-05 @ 4:49 PM
Last Modification Date:
2024-10-26 @ 9:24 AM
Study NCT ID:
NCT00321191
Status:
COMPLETED
Last Update Posted:
2015-06-24
First Post:
2006-05-02
Brief Title:
Measurement of the Second Gas Effect on Sevoflurane in Anaesthetised Patients
Sponsor:
Austin Health
Organization:
Austin Health
Study Overview
Official Title:
Measurement of the Second Gas Effect on Sevoflurane in Anaesthetised Patients
Status:
COMPLETED
Status Verified Date:
2008-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is investigating the second gas effect a phenomenon produced by the uptake of nitrous oxide N2O by the lungs during the course of a typical anaesthetic The effect is to increase the concentration of other breathed gases in the lung These include oxygen and volatile anaesthetic agents such as sevoflurane which are also normally administered along with N2O We wish to i measure the magnitude of the second gas effects on both blood and expired concentrations of sevoflurane Part 1 and ii see if a demonstrable difference exists between the effects on blood and expired concentrations
Detailed Description:
This study is investigating the second gas effect a phenomenon produced by the uptake of nitrous oxide N2O by the lungs during the course of a typical anaesthetic The effect is to increase the concentration of other breathed gases in the lung These include oxygen and volatile anaesthetic agents such as sevoflurane which are also normally administered along with N2O
While the second gas effect has been demonstrated previously by measuring the concentration of volatile anaesthetic in the expired breath no study has yet shown that it has a significant effect on the concentrations in the blood The blood concentration is in fact more important as it directly determines the concentration of anaesthetic reaching the brain and therefore the effect on the depth of anaesthesia The second gas effect on blood concentrations may be more powerful than that on expired concentrations due to the detrimental effect of anaesthesia on the evenness of distribution of ventilation and blood flow in the lung
The proposed study will have two parallel components or Parts We wish to i measure the magnitude of the second gas effects on both blood and expired concentrations of sevoflurane Part 1 and ii see if a demonstrable difference exists between the effects on blood and expired concentrations
While the second gas effect has been demonstrated previously by measuring the concentration of volatile anaesthetic in the expired breath no study has yet shown that it has a significant effect on the concentrations in the blood The blood concentration is in fact more important as it directly determines the concentration of anaesthetic reaching the brain and therefore the effect on the depth of anaesthesia The second gas effect on blood concentrations may be more powerful than that on expired concentrations due to the detrimental effect of anaesthesia on the evenness of distribution of ventilation and blood flow in the lung
The proposed study will have two parallel components or Parts We wish to i measure the magnitude of the second gas effects on both blood and expired concentrations of sevoflurane Part 1 and ii see if a demonstrable difference exists between the effects on blood and expired concentrations
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None