Ignite Creation Date:
2024-05-06 @ 12:12 PM
Last Modification Date:
2024-10-26 @ 12:55 PM
Study NCT ID:
NCT03701737
Status:
COMPLETED
Last Update Posted:
2023-09-29
First Post:
2018-10-08
Brief Title:
Study of Eating Behaviour and Sense of Taste Before and After Treatment With Nocturnal Continuous Positive Airway Pressure in Overweight Patients With Obstructive Sleep Apnea Syndrome
Sponsor:
Centre Hospitalier Universitaire Dijon
Organization:
Centre Hospitalier Universitaire Dijon
Study Overview
Official Title:
Study of Eating Behaviour and Sense of Taste Before and After Treatment With Nocturnal Continuous Positive Airway Pressure in Overweight Patients With Obstructive Sleep Apnoea Syndrome
Status:
COMPLETED
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GOUSAS
Brief Summary:
Obstructive sleep apnea OSA is characterized by a repeated partial or complete obstruction of the airway that results in a intermittent hypoxia and sleep disturbance
A complex and reciprocal link between obesity and OSA exists On the one hand obesity is one of the main risk factors for OSA On the other hand OSA seems to promote obesity The changes in sleep patterns that characterize OSA alter energy metabolism and promote weight gain In particular OSA is associated with metabolic disturbances decreased physical activity and changes in energy expenditure resulting in weight gain OSA is characterized by resistance to leptin which reduces the feeling of satiety and an increase in ghrelin levels which increases the feeling of hunger
There may be an increase in food intake but very few studies have looked at this aspect Our current knowledge is based on simple patient reports of the amount of food consumed per 24 hours
First-line treatment of OSA is based on continuous positive airway pressure CPAP but this approach is not curative and weight loss is encouraged CAPP could facilitate weight loss by restoring sleep quality Paradoxically recent studies show weight gain proportional to the duration of use of CPP Randomized controlled trials offering apneic patients a return to physical activity and hygiene-dietary rules have shown an improvement in OSA after weight loss
A better understanding of the influence of OSA and its treatment on the energy balance through food preferences and olfacto-gustatory sensoriality is an essential prerequisite for personalized nutritional management In the face of unexpected weight gain under CPP this type of intervention would be all the more beneficial as OSA and obesity are public health problems representing two independent risk factors for cardiovascular morbidity and mortality with increasing incidence
We hypothesize that the treatment of OSA with CPAP changes food preferences in favour of fatty and sugary high-calorie foods
A complex and reciprocal link between obesity and OSA exists On the one hand obesity is one of the main risk factors for OSA On the other hand OSA seems to promote obesity The changes in sleep patterns that characterize OSA alter energy metabolism and promote weight gain In particular OSA is associated with metabolic disturbances decreased physical activity and changes in energy expenditure resulting in weight gain OSA is characterized by resistance to leptin which reduces the feeling of satiety and an increase in ghrelin levels which increases the feeling of hunger
There may be an increase in food intake but very few studies have looked at this aspect Our current knowledge is based on simple patient reports of the amount of food consumed per 24 hours
First-line treatment of OSA is based on continuous positive airway pressure CPAP but this approach is not curative and weight loss is encouraged CAPP could facilitate weight loss by restoring sleep quality Paradoxically recent studies show weight gain proportional to the duration of use of CPP Randomized controlled trials offering apneic patients a return to physical activity and hygiene-dietary rules have shown an improvement in OSA after weight loss
A better understanding of the influence of OSA and its treatment on the energy balance through food preferences and olfacto-gustatory sensoriality is an essential prerequisite for personalized nutritional management In the face of unexpected weight gain under CPP this type of intervention would be all the more beneficial as OSA and obesity are public health problems representing two independent risk factors for cardiovascular morbidity and mortality with increasing incidence
We hypothesize that the treatment of OSA with CPAP changes food preferences in favour of fatty and sugary high-calorie foods
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None